从益生菌酵母布拉氏酵母基因组序列中获得进化见解。
Gleaning evolutionary insights from the genome sequence of a probiotic yeast Saccharomyces boulardii.
机构信息
CSIR-Institute of Microbial Technology, Chandigarh, India.
出版信息
Gut Pathog. 2013 Oct 22;5(1):30. doi: 10.1186/1757-4749-5-30.
BACKGROUND
The yeast Saccharomyces boulardii is used worldwide as a probiotic to alleviate the effects of several gastrointestinal diseases and control antibiotics-associated diarrhea. While many studies report the probiotic effects of S. boulardii, no genome information for this yeast is currently available in the public domain.
RESULTS
We report the 11.4 Mbp draft genome of this probiotic yeast. The draft genome was obtained by assembling Roche 454 FLX + shotgun data into 194 contigs with an N50 of 251 Kbp. We compare our draft genome with all other Saccharomyces cerevisiae genomes.
CONCLUSIONS
Our analysis confirms the close similarity of S. boulardii to S. cerevisiae strains and provides a framework to understand the probiotic effects of this yeast, which exhibits unique physiological and metabolic properties.
背景
酵母布拉氏酵母被广泛用作益生菌，以减轻多种胃肠道疾病的影响，并控制抗生素相关性腹泻。虽然许多研究报告了 S. boulardii 的益生菌作用，但目前在公共领域中尚无该酵母的基因组信息。
结果
我们报告了这种益生菌酵母的 11.4 Mbp 草图基因组。通过将罗氏 454 FLX + 鸟枪法数据组装成 194 个 contigs，N50 为 251 Kbp，获得了该草图基因组。我们将我们的草图基因组与所有其他酿酒酵母基因组进行了比较。
结论
我们的分析证实了 S. boulardii 与 S. cerevisiae 菌株的密切相似性，并为理解该酵母的益生菌作用提供了一个框架，该酵母表现出独特的生理和代谢特性。
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