心脏再同步治疗模块注册研究：心电图和治疗反应的预测因素（NCT01573091）。
Cardiac Resynchronization Therapy MOdular REgistry: ECG and Rx predictors of response to cardiac resynchronization therapy (NCT01573091).
机构信息
aClinica Mediterranea, Napoli bUniversità di Padova, Padova cOspedale S'Anna, San Fermo della Battaglia (CO) dOspedale SS Trinità, Cagliari eOspedale Gavazzeni, Bergamo fOspedale Carlo Poma, Mantova gOspedale Sant'Antonio Abate, Gallarate (VA) hClinica San Michele, Maddaloni (CE) iOspedale Monaldi, Napoli jOspedale Poliambulanza, Brescia kOspedale Panico, Tricase (LE) lOspedale Pugliese-Ciaccio, Catanzaro mOspedale SS Giacomo e Cristoforo, Massa nBoston Scientific Italia, Milan oOspedale Careggi, Università di Firenze, Firenze, Italy.
出版信息
J Cardiovasc Med (Hagerstown). 2013 Dec;14(12):886-93. doi: 10.2459/JCM.0b013e3283644bb2.
AIMS
A variable proportion, up to 30%, of patients who undergo cardiac resynchronization therapy (CRT) do not benefit from treatment. The aim of the Cardiac Resynchronization Therapy MOdular REgistry (CRT MORE) is to determine whether specific electrocardiographic and radiographic parameters can be used to predict clinical and echocardiographic response to CRT.
METHODS
The CRT MORE is a prospective, single-arm, multicenter cohort study designed to evaluate the electrocardiographic and radiographic predictors of response to CRT. All study patients receive a pacemaker or implantable defibrillator for CRT delivery in accordance with current guidelines. Enrollment started in December 2011 and is scheduled to end in November 2013. Approximately 1100 consecutive patients will be enrolled in 30 Italian centers and will be followed up for 60 months after implantation. The primary endpoint is the improvement in clinical (Clinical Composite Score) and echocardiographic (a decrease of ≥ 15% in left ventricular end-systolic volume) parameters at the 6-month follow-up visit.
CONCLUSION
This study might provide important information about which electrocardiographic and radiographic parameters better predict CRT response.
目的
接受心脏再同步治疗（CRT）的患者中，有 30%的比例可能无法从中受益。心脏再同步治疗模块注册研究（CRT MORE）旨在确定特定的心电图和影像学参数是否可用于预测 CRT 治疗的临床和超声心动图反应。
方法
CRT MORE 是一项前瞻性、单臂、多中心队列研究，旨在评估心电图和影像学参数对 CRT 反应的预测价值。所有研究患者均根据当前指南接受 CRT 输送的起搏器或植入式除颤器。该研究于 2011 年 12 月开始，计划于 2013 年 11 月结束。大约 1100 例连续患者将被纳入 30 个意大利中心，并在植入后 60 个月进行随访。主要终点是 6 个月随访时临床（综合临床评分）和超声心动图（左心室收缩末期容积减少≥15%）参数的改善。
结论
该研究可能提供有关哪些心电图和影像学参数能更好地预测 CRT 反应的重要信息。
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