Department of Pulmonary Diseases, Ataturk University School of Medicine, Erzurum, Turkey.
Med Sci Monit. 2013 Oct 23;19:883-7. doi: 10.12659/MSM.889619.
Hypothyroidism and obstructive sleep apnea (OSA) are both common health problems and can be seen together. Each of these 2 diseases can cause pulmonary hypertension (PH). We aimed to determine whether hypothyroidism with OSA has a significant effect on the frequency and severity of PH.
A total of 236 patients were included in the study. Patients were divided into 3 groups: Group I, Obstructive Sleep Apnea (n=149); Group II, Hypothyroidism (n=56); and Group III, Obstructive Sleep Apnea-Hypothyroidism (n=31). All patients underwent polysomnography and echocardiography and serum levels of thyroid-stimulating hormone (TSH) and free thyroxine 4 (FT4) were analyzed.
There were 167 male and 69 female participants, and the mean age was 47.8 ± 11.5 (Group I: 81.9% male, 18.1% female; Group II: 44.6% male, 55.4% female; Group III: 64.6% male, 35.4% female). Distribution of mean pulmonary arterial pressure on echocardiography was statistically different among the 3 groups (x(2)=14.99, p=0.006). When adjusted according to the apnea-hypopnea index (AHI), age, and body mass index (BMI), a significant relation with PH was determined (p=0.002).
The combination of hypothyroidism with OSA is associated with an increased frequency and severity of PH. When PH is found out of line with the severity of OSA, thyroid dysfunction should be investigated.
甲状腺功能减退症和阻塞性睡眠呼吸暂停(OSA)都是常见的健康问题,可同时出现。这两种疾病都会导致肺动脉高压(PH)。我们旨在确定甲状腺功能减退症伴 OSA 是否对 PH 的频率和严重程度有显著影响。
共有 236 名患者纳入本研究。患者被分为 3 组:组 I,阻塞性睡眠呼吸暂停(n=149);组 II,甲状腺功能减退症(n=56);组 III,阻塞性睡眠呼吸暂停合并甲状腺功能减退症(n=31)。所有患者均接受多导睡眠图和超声心动图检查,并分析促甲状腺激素(TSH)和游离甲状腺素 4(FT4)的血清水平。
患者中男性 167 例,女性 69 例,平均年龄为 47.8±11.5(组 I:男性占 81.9%,女性占 18.1%;组 II:男性占 44.6%,女性占 55.4%;组 III:男性占 64.6%,女性占 35.4%)。3 组间超声心动图平均肺动脉压的分布存在统计学差异(x²=14.99,p=0.006)。在校正了呼吸暂停低通气指数(AHI)、年龄和体重指数(BMI)后,发现与 PH 有显著相关性(p=0.002)。
甲状腺功能减退症合并 OSA 与 PH 的频率和严重程度增加有关。当 PH 与 OSA 的严重程度不相符时,应调查甲状腺功能障碍。