Suppr超能文献

阻塞性睡眠呼吸暂停伴甲状腺功能减退症患者的肺动脉高压发生率和严重程度。

The incidence and severity of pulmonary hypertension in obstructive sleep apnea with hypothyroidism.

机构信息

Department of Pulmonary Diseases, Ataturk University School of Medicine, Erzurum, Turkey.

出版信息

Med Sci Monit. 2013 Oct 23;19:883-7. doi: 10.12659/MSM.889619.

Abstract

BACKGROUND

Hypothyroidism and obstructive sleep apnea (OSA) are both common health problems and can be seen together. Each of these 2 diseases can cause pulmonary hypertension (PH). We aimed to determine whether hypothyroidism with OSA has a significant effect on the frequency and severity of PH.

MATERIAL AND METHODS

A total of 236 patients were included in the study. Patients were divided into 3 groups: Group I, Obstructive Sleep Apnea (n=149); Group II, Hypothyroidism (n=56); and Group III, Obstructive Sleep Apnea-Hypothyroidism (n=31). All patients underwent polysomnography and echocardiography and serum levels of thyroid-stimulating hormone (TSH) and free thyroxine 4 (FT4) were analyzed.

RESULTS

There were 167 male and 69 female participants, and the mean age was 47.8 ± 11.5 (Group I: 81.9% male, 18.1% female; Group II: 44.6% male, 55.4% female; Group III: 64.6% male, 35.4% female). Distribution of mean pulmonary arterial pressure on echocardiography was statistically different among the 3 groups (x(2)=14.99, p=0.006). When adjusted according to the apnea-hypopnea index (AHI), age, and body mass index (BMI), a significant relation with PH was determined (p=0.002).

CONCLUSIONS

The combination of hypothyroidism with OSA is associated with an increased frequency and severity of PH. When PH is found out of line with the severity of OSA, thyroid dysfunction should be investigated.

摘要

背景

甲状腺功能减退症和阻塞性睡眠呼吸暂停(OSA)都是常见的健康问题,可同时出现。这两种疾病都会导致肺动脉高压(PH)。我们旨在确定甲状腺功能减退症伴 OSA 是否对 PH 的频率和严重程度有显著影响。

材料和方法

共有 236 名患者纳入本研究。患者被分为 3 组:组 I,阻塞性睡眠呼吸暂停(n=149);组 II,甲状腺功能减退症(n=56);组 III,阻塞性睡眠呼吸暂停合并甲状腺功能减退症(n=31)。所有患者均接受多导睡眠图和超声心动图检查,并分析促甲状腺激素(TSH)和游离甲状腺素 4(FT4)的血清水平。

结果

患者中男性 167 例,女性 69 例,平均年龄为 47.8±11.5(组 I:男性占 81.9%,女性占 18.1%;组 II:男性占 44.6%,女性占 55.4%;组 III:男性占 64.6%,女性占 35.4%)。3 组间超声心动图平均肺动脉压的分布存在统计学差异(x²=14.99,p=0.006)。在校正了呼吸暂停低通气指数(AHI)、年龄和体重指数(BMI)后,发现与 PH 有显著相关性(p=0.002)。

结论

甲状腺功能减退症合并 OSA 与 PH 的频率和严重程度增加有关。当 PH 与 OSA 的严重程度不相符时,应调查甲状腺功能障碍。

相似文献

2
Obstructive sleep apnea in hypothyroidism.
Ann Afr Med. 2022 Oct-Dec;21(4):403-409. doi: 10.4103/aam.aam_134_21.
3
Pulmonary hypertension and echocardiogram parameters in obstructive sleep apnea.
Eur Arch Otorhinolaryngol. 2017 Jun;274(6):2601-2606. doi: 10.1007/s00405-017-4491-1. Epub 2017 Feb 27.
4
5
Prevalence of newly established thyroid disorders in patients with moderate-to-severe obstructive sleep apnea syndrome.
Sleep Breath. 2019 Jun;23(2):567-573. doi: 10.1007/s11325-018-1746-z. Epub 2018 Oct 27.
6
Prevalence of thyroid disease in patients with obstructive sleep apnea.
Respir Med. 2011 Nov;105(11):1755-60. doi: 10.1016/j.rmed.2011.07.007. Epub 2011 Aug 4.
7
Impact of obstructive sleep apnea on pulmonary hypertension in patients with chronic obstructive pulmonary disease.
Chin Med J (Engl). 2019 Jun 5;132(11):1272-1282. doi: 10.1097/CM9.0000000000000247.
9
Relationship between sleep apnea and thyroid function.
Sleep Breath. 2015 Mar;19(1):85-9. doi: 10.1007/s11325-014-0966-0. Epub 2014 Mar 13.

引用本文的文献

1
Pulmonary hypertension in thyroid diseases.
Endocrine. 2016 Dec;54(3):578-587. doi: 10.1007/s12020-016-0923-8. Epub 2016 Mar 19.

本文引用的文献

1
Treatment of pulmonary hypertension.
Med Sci Monit. 2012 Apr;18(4):RA31-9. doi: 10.12659/msm.882607.
2
Diagnosis and management of pulmonary arterial hypertension.
Pulm Med. 2011;2011:845864. doi: 10.1155/2011/845864. Epub 2011 Sep 20.
3
Prevalence of thyroid disease in patients with obstructive sleep apnea.
Respir Med. 2011 Nov;105(11):1755-60. doi: 10.1016/j.rmed.2011.07.007. Epub 2011 Aug 4.
4
Endocrine aspects of obstructive sleep apnea.
J Clin Endocrinol Metab. 2010 Feb;95(2):483-95. doi: 10.1210/jc.2009-1912. Epub 2010 Jan 8.
6
Development and pathology of pulmonary hypertension.
J Am Coll Cardiol. 2009 Jun 30;54(1 Suppl):S3-S9. doi: 10.1016/j.jacc.2009.04.009.
7
The new AASM criteria for scoring hypopneas: impact on the apnea hypopnea index.
Sleep. 2009 Feb;32(2):150-7. doi: 10.1093/sleep/32.2.150.
8
Pulmonary hypertension and thyroid disease.
Chest. 2007 Sep;132(3):793-7. doi: 10.1378/chest.07-0366. Epub 2007 Jul 23.
9
Should women with obstructive sleep apnea syndrome be screened for hypothyroidism?
Sleep Breath. 2003 Dec;7(4):185-8. doi: 10.1007/s11325-003-0185-6.
10
Sleep apnea syndrome in endocrine diseases.
Respiration. 2003 May-Jun;70(3):320-7. doi: 10.1159/000072019.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验