Miller Chad M, Husain Aatif M
Department of Medicine (Neurology), Duke University, Durham, North Carolina 27710, USA.
Sleep Breath. 2003 Dec;7(4):185-8. doi: 10.1007/s11325-003-0185-6.
This study was conducted to determine if there is a significant increase in prevalence of hypothyroidism in women with OSAS such that screening might be warranted. Women undergoing polysomnography (PSG) at Duke University between January 1, 2000 and August 21, 2001 were considered for enrollment. Those with a respiratory disturbance index (RDI) >/= 10 were included for further analysis. Demographic data and documentation of thyroid testing was obtained. Thyroid testing obtained within 1 year of the PSG was used for this study. Demographic data of the euthyroid and hypothyroid groups were compared. Prevalence of hypothyroidism was calculated and compared with the prevalence of hypothyroidism in the Framingham study. A total of 118 women had OSAS per PSG. Seventy-five patients had thyroid function testing within 1 year of PSG evaluation. The mean age, body mass index, and RDI in the euthyroid and hypothyroid groups were not significantly different. The prevalence of hypothyroidism was 9.3%; the established prevalence of hypothyroidism in women in the general population is 5.9%. There was no statistically significant difference in the prevalence between these groups. The prevalence of hypothyroidism in women with OSAS is no higher than that seen in the general population. Screening women with symptoms of OSAS for hypothyroidism is unlikely to be useful.
本研究旨在确定阻塞性睡眠呼吸暂停低通气综合征（OSAS）女性患者甲状腺功能减退症的患病率是否显著增加，从而判断是否有必要进行筛查。2000年1月1日至2001年8月21日期间在杜克大学接受多导睡眠图（PSG）检查的女性被纳入研究。呼吸紊乱指数（RDI）≥10的患者被纳入进一步分析。收集人口统计学数据及甲状腺检查记录。本研究使用PSG检查前1年内的甲状腺检查结果。比较甲状腺功能正常组和甲状腺功能减退组的人口统计学数据。计算甲状腺功能减退症的患病率，并与弗明汉姆研究中甲状腺功能减退症的患病率进行比较。每次PSG检查共有118名女性患有OSAS。75名患者在PSG评估前1年内进行了甲状腺功能检查。甲状腺功能正常组和甲状腺功能减退组的平均年龄、体重指数和RDI无显著差异。甲状腺功能减退症的患病率为9.3%；一般人群中女性甲状腺功能减退症的既定患病率为5.9%。两组患病率之间无统计学显著差异。OSAS女性患者甲状腺功能减退症的患病率不高于一般人群。对有OSAS症状的女性进行甲状腺功能减退症筛查不太可能有用。
