Larsson B, Lalos O, Marsk L, Tronstad S E, Bygdeman M, Pehrson S, Joelsson I
Acta Obstet Gynecol Scand. 1985;64(5):437-41. doi: 10.3109/00016348509155163.
The intraperitoneal instillation of 32% dextran 70 (HyskonR, Pharmacia AB, Sweden) has previously been reported to prevent the formation of postoperative adhesions. Against this background, the present study was undertaken to evaluate the efficacy of HyskonR in counteracting peritoneal adhesions following tubal microsurgery. 105 infertile women were operated upon in a prospective, randomized, controlled, double-blind, multicenter study. The intra-abdominal adhesions present from the beginning were classified by means of a standardized scoring scale and the extent of adhesions was again evaluated at follow-up laparoscopy 4-10 weeks later. A reduction in the extent of the intra-abdominal adhesions (statistically highly significant) was revealed in both the Hyskon group and the saline control group. The extent of adhesions in the Hyskon group was not lesser than in the saline group, however. The pregnancy rates in the two groups were also similar.
先前已有报道称，腹腔内注入32%的右旋糖酐70（瑞典法玛西亚公司的HyskonR）可预防术后粘连的形成。在此背景下，本研究旨在评估HyskonR在输卵管显微手术后对抗腹膜粘连的疗效。在一项前瞻性、随机、对照、双盲、多中心研究中，对105名不孕女性进行了手术。最初存在的腹腔内粘连通过标准化评分量表进行分类，并在4 - 10周后的随访腹腔镜检查中再次评估粘连程度。Hyskon组和生理盐水对照组的腹腔内粘连程度均有降低（具有统计学高度显著性）。然而，Hyskon组的粘连程度并不低于生理盐水组。两组的妊娠率也相似。
