Dahlstrand C, Edin R, Dahlström A, Ahlman H
Acta Physiol Scand. 1985 Mar;123(3):355-62. doi: 10.1111/j.1748-1716.1985.tb07600.x.
An in vivo model for the simultaneous study of motility of the gallbladder, sphincter of Oddi and the duodenal wall in species with an intraduodenal location of the sphincter has been developed. Gallbladder motility is registered by manometry, while trans-sphincteric flow and duodenal wall motility are recorded by perfusion methods. The sphincter of Oddi proper is totally uninfluenced by any mechanical procedures since the outflow of fluid is collected via a funnel-shaped human femoral vein graft fixed to the duodenal mucosa by tiny sutures peripheral to the sphincteric muscle. The motility of the duodenal wall influences the flow of saline through a small feline vein graft inserted across the duodenal wall. The method is described in detail as well as nerve stimulation experiments and some pharmacological tests (e.g. infusion of substance P) to demonstrate the usefulness of the method. With this method the physiology and pharmacology of this region can be investigated in species, which, like man, have an intraduodenal location of the sphincter of Oddi.
已经建立了一种体内模型，用于同时研究胆囊、Oddi括约肌和十二指肠壁的运动，该模型适用于Oddi括约肌位于十二指肠内的物种。胆囊运动通过测压法记录，而跨括约肌流量和十二指肠壁运动则通过灌注法记录。由于液体流出是通过一个漏斗形的人股静脉移植物收集的，该移植物通过括约肌周围的微小缝线固定在十二指肠黏膜上，因此Oddi括约肌本身完全不受任何机械操作的影响。十二指肠壁的运动影响通过插入十二指肠壁的小型猫科动物静脉移植物的盐水流量。文中详细描述了该方法以及神经刺激实验和一些药理学测试（如P物质输注），以证明该方法的实用性。通过这种方法，可以在与人类一样Oddi括约肌位于十二指肠内的物种中研究该区域的生理学和药理学。
