鼠伤寒沙门氏菌生物膜形成和抗生素耐药性受不同核糖核酸酶的影响。
Biofilm formation and antibiotic resistance in Salmonella Typhimurium are affected by different ribonucleases.
机构信息
Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Oeiras, Portugal.
出版信息
J Microbiol Biotechnol. 2014 Jan;24(1):8-12. doi: 10.4014/jmb.1309.09046.
PMID:24150497
Abstract
Biofilm formation and antibiotic resistance are important determinants for bacterial pathogenicity. Ribonucleases control RNA degradation and there is increasing evidence that they have an important role in virulence mechanisms. In this report, we show that ribonucleases affect susceptibility against ribosome-targeting antibiotics and biofilm formation in Salmonella.
摘要
生物膜形成和抗生素耐药性是细菌致病性的重要决定因素。核糖核酸酶控制 RNA 降解，越来越多的证据表明它们在毒力机制中起重要作用。在本报告中，我们表明核糖核酸酶影响沙门氏菌对核糖体靶向抗生素的敏感性和生物膜形成。
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