Palva T, Lehto V P, Johnsson L G, Virtanen I, Mäkinen J
Arch Otolaryngol. 1985 Dec;111(12):786-91. doi: 10.1001/archotol.1985.00800140030004.
Large cholesterol cysts were found in revision surgery in six patients with previous ear surgery one to 28 years ago. The cysts mimicked brain herniation in open cavities, filled the mastoid and ear canal in closed cavities, or caused postauricular swelling. Bone around the cysts was soft and granulomatous. Secretory cells were scarce in the epithelial lining of the lumen, but subepithelial glands were frequent. Cholesterol granulomas and hemosiderin-laden macrophages were present inside the wall. The cyst lining and the glands under it showed cytokeratin staining typical for simple and glandular epithelia. Antiprekeratin antibodies showed no decoration of the lining but reacted positively with the meatal skin. These findings prove that respiratory-type epithelium separated from an aerated middle ear does not undergo changes into keratin-forming epithelium.
在1至28年前曾接受过耳部手术的6例患者的翻修手术中发现了大型胆固醇囊肿。这些囊肿在开放腔隙中类似脑疝，在封闭腔隙中充满乳突和耳道，或导致耳后肿胀。囊肿周围的骨质柔软且呈肉芽肿性。管腔内衬上皮中的分泌细胞稀少，但上皮下腺体常见。囊肿壁内存在胆固醇肉芽肿和含铁血黄素巨噬细胞。囊肿内衬及其下方的腺体显示出简单上皮和腺上皮典型的细胞角蛋白染色。抗前角蛋白抗体未显示内衬有染色，但与耳道皮肤呈阳性反应。这些发现证明，从中耳充气部分分离出来的呼吸型上皮不会转变为形成角蛋白的上皮。
