Doust Jenny, Glasziou Paul
Centre for Research in Evidence Based Practice, Bond University, Robina, Qld 4429, Australia.
Clin Biochem Rev. 2013 Aug;34(2):85-92.
Monitoring tests form an increasing proportion of the workload in clinical biochemistry and biochemists can help by providing clinicians with information about the variability and precision of tests, the time frame for pharmacodynamic stabilisation after a treatment change, and the frequency of testing. This paper outlines the phases of monitoring, and how to decide if monitoring is beneficial, which test to use for monitoring, when a change in the test result indicates a need for the change in treatment and the length of testing intervals. We conclude with some recommendations for biochemists for future areas of research and advice that can be given to clinicians.
监测测试在临床生物化学工作量中所占比例日益增加，生物化学家可以通过向临床医生提供有关测试的变异性和精密度、治疗改变后药效学稳定的时间框架以及测试频率等信息来提供帮助。本文概述了监测的各个阶段，以及如何确定监测是否有益、用于监测的测试方法、测试结果的变化何时表明需要改变治疗以及测试间隔的时长。我们最后为生物化学家提出了一些关于未来研究领域的建议，以及可以提供给临床医生的建议。
