[Effect of pyromecaine on ionic currents in electrically excitable membranes].

The effects of the local anesthetic pyromecaine on the action potential parameters of the guinea-pig heart ventricular cardiomyocytes as well as on Na and K ionic currents of the neurons in the rat spinal ganglions have been studied. Pyromecaine was shown to reduce preferentially the first derivative of the ascending phase of cardiomyocyte action potential suggesting the blocking action of the anesthetic on the fast sodium inward current. The experiments on the isolated neurons in the rat spinal ganglions have shown that interaction of pyromecaine with inactivated Na+ channels makes a considerable contribution to the blocking effect of anesthesia.