以近红外吸收金纳米结构作为光学不透明示踪剂的非电离光声膀胱造影术。
Nonionizing photoacoustic cystography with near-infrared absorbing gold nanostructures as optical-opaque tracers.
作者信息
Jeon Mansik, Jenkins Samir, Oh Junghwan, Kim Jeehyun, Peterson Tara, Chen Jingyi, Kim Chulhong
机构信息
Department of Creative IT Engineering, Pohang University of Science & Technology, Pohang, 790-784, Republic of Korea.
出版信息
Nanomedicine (Lond). 2014 Jul;9(9):1377-88. doi: 10.2217/nnm.13.103. Epub 2013 Oct 23.
AIM
The objectives of this study were to demonstrate nonionizing photoacoustic tomography (PAT) of bladders with near-infrared absorbing gold nanocages (GNCs) as an optical-turbid tracer and to investigate the fate of GNCs after photoacoustic imaging.
MATERIALS & METHODS: The rats' bladders were visualized using PAT after transurethral injection of 2-nM GNCs. The fate of GNCs in the bladders was investigated. Spectroscopic PAT was applied to identify GNC-filled bladders in vivo and study biodistribution ex vivo.
RESULTS
Rats' bladders filled with GNCs were successfully imaged using a PAT system. The photoacoustic amplitude was enhanced by approximately 2240%. Both in vivo and ex vivo PAT results reveal that no accumulation of GNCs in the bladder and kidney was observed, and were validated with inductively coupled plasma mass spectrometry.
CONCLUSION
The PAT with transurethral injection of GNCs provides two crucial safety features for clinical translation: no radiation exposure and no long-term heavy metal accumulation.
目的
本研究的目的是展示以近红外吸收金纳米笼（GNCs）作为光学混浊示踪剂对膀胱进行非电离光声断层扫描（PAT），并研究光声成像后GNCs的去向。
材料与方法
经尿道注射2 nM GNCs后，使用PAT对大鼠膀胱进行可视化。研究了GNCs在膀胱中的去向。应用光谱PAT在体内识别充满GNCs的膀胱，并在体外研究生物分布。
结果
使用PAT系统成功对充满GNCs的大鼠膀胱进行了成像。光声振幅提高了约2240%。体内和体外PAT结果均显示，未观察到GNCs在膀胱和肾脏中的蓄积，电感耦合等离子体质谱法验证了这一结果。
结论
经尿道注射GNCs的PAT为临床转化提供了两个关键的安全特性：无辐射暴露和无长期重金属蓄积。
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