Department of Internal Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan.
Diabet Med. 2014 Apr;31(4):419-24. doi: 10.1111/dme.12343. Epub 2013 Nov 22.
Diabetes mellitus has been increasing in Mongolia. There is also growing concern about the relationship between iron stores and the severity of type 2 diabetes. In this study, we aimed to evaluate serum ferritin level among Mongolian individuals with and without diabetes.
Of 254 participants, a total of 99 previously diagnosed patients with type 2 diabetes and the same numbers of subjects without diabetes were enrolled and invited to a physical examination (BMI, central obesity, blood pressure) and fasting blood tests (fasting blood glucose, HbA1c , serum ferritin, C-reactive protein, aspartate aminotransferase, alanine transferase).
Serum ferritin was higher in the patients with type 2 diabetes compared with the control group without diabetes, with a significant difference in the female groups (341.6 ± 67.2 and 159.1 ± 36.8 ng/ml respectively, P = 0.019). Of the patients with type 2 diabetes, 43.4% had hyperferritinaemia, and 21.2% of the individuals without diabetes had hyperferritinaemia. In the group with type 2 diabetes, serum ferritin level was significantly higher in the group of women whose HbA1c was ≥ 53 mmol/mol (7.0%) compared with the other group of women whose HbA1c was < 53 mmol/mol (7.0%) (562.1 ± 122.1 and 220.5 ± 78.7 ng/ml respectively, P = 0.025). We also found that the subjects without diabetes, aged over 55 years, are at risk of increased serum ferritin.
Poorly controlled patients with type 2 diabetes and people without diabetes of over 55 years of age are likely to be at a higher risk of developing hyperferritinaemia. Thus, regular assessments of serum ferritin might be important for those who are at risk of hyperferritnaemia for prevention and an early intervention.
糖尿病在蒙古呈上升趋势。人们越来越关注铁储存量与 2 型糖尿病严重程度之间的关系。本研究旨在评估蒙古 2 型糖尿病患者和非糖尿病患者的血清铁蛋白水平。
在 254 名参与者中，共纳入了 99 名先前确诊的 2 型糖尿病患者和相同数量的非糖尿病患者，并邀请他们进行体检（BMI、中心性肥胖、血压）和空腹血检（空腹血糖、HbA1c、血清铁蛋白、C 反应蛋白、天门冬氨酸氨基转移酶、丙氨酸氨基转移酶）。
与无糖尿病的对照组相比，2 型糖尿病患者的血清铁蛋白水平更高，女性组差异有统计学意义（分别为 341.6 ± 67.2 和 159.1 ± 36.8ng/ml，P=0.019）。在 2 型糖尿病患者中，43.4%的患者存在铁蛋白血症，而无糖尿病的患者中，21.2%的患者存在铁蛋白血症。在 2 型糖尿病组中，HbA1c≥53mmol/mol（7.0%）的女性组血清铁蛋白水平明显高于 HbA1c<53mmol/mol（7.0%）的女性组（分别为 562.1 ± 122.1 和 220.5 ± 78.7ng/ml，P=0.025）。我们还发现，55 岁以上无糖尿病的受试者发生血清铁蛋白升高的风险增加。
血糖控制不佳的 2 型糖尿病患者和 55 岁以上无糖尿病的人群可能更容易发生铁蛋白血症。因此，对于有发生铁蛋白血症风险的人群，定期评估血清铁蛋白可能有助于预防和早期干预。
