Ke Yazhen, Zhi Xiaoyan, Yu Xiang, Ding Guodong, Yang Chun, Xu Hui
Laboratory of Pharmaceutical Design & Synthesis, College of Sciences, Northwest A&F University, Yangling 712100, China.
Comb Chem High Throughput Screen. 2014 Jan;17(1):89-95. doi: 10.2174/13862073113166660058.
A chemically diverse library of benzimidazole-azo-phenol derivatives was efficiently prepared and screened for their antifungal activities against five phytopathogenic fungi. Some compounds exhibited potent antifungal activities. As compared with a commercially available agricultural fungicide, hymexazol, especially compound V-5 showed the most promising broad-spectrum antifungal activities against five phytopathogenic fungi. The EC50 values of V-5 against F. graminearum, A. solani, V. mali, B. cinerea, and C. lunata were 0.09, 0.08, 0.06, 0.07, and 0.11 μmol/mL, respectively.
高效制备了一个化学结构多样的苯并咪唑-偶氮-苯酚衍生物库，并对其针对五种植物病原真菌的抗真菌活性进行了筛选。一些化合物表现出强效抗真菌活性。与市售农用杀菌剂恶霉灵相比，尤其是化合物V-5对五种植物病原真菌表现出最具前景的广谱抗真菌活性。V-5对禾谷镰刀菌、茄链格孢、苹果轮纹病菌、灰葡萄孢和新月弯孢霉的EC50值分别为0.09、0.08、0.06、0.07和0.11 μmol/mL。
