Laboratory of Pharmaceutical Design and Synthesis, College of Sciences, Northwest A&F University, Yangling 712100, China.
Bioorg Med Chem Lett. 2010 Jul 15;20(14):4193-5. doi: 10.1016/j.bmcl.2010.05.048. Epub 2010 May 20.
As compared with a commercially available agricultural fungicide hymexazol, some phenyl-azo phenol derivatives (e.g., 4a, 4b, 4f, 4n, 4q, 4u, and 4v) exhibited the more promising and pronounced antifungal activities in vitro against seven phytopathogenic fungi. It seemed that 4-((un)substituted phenylazo)-phenol and 4-((un)substituted phenylazo)-3-methylphenol might be considered as new lead structures for further design of agricultural fungicides.
与市售农用杀菌剂 hymexazol 相比，一些苯偶氮苯酚衍生物（例如 4a、4b、4f、4n、4q、4u 和 4v）在体外对七种植物病原菌显示出更有希望和更显著的抗真菌活性。似乎 4-((未)取代的苯偶氮基)-苯酚和 4-((未)取代的苯偶氮基)-3-甲基苯酚可能被认为是进一步设计农用杀菌剂的新的先导结构。
