Masson Walter, Galimberti María L, Anselmi Carolina L, Cagide Arturo, Galimberti Ricardo L
Servicio de Cardiología, Hospital Italiano de Buenos Aires.
Medicina (B Aires). 2013;73(5):423-7.
In previous reports, psoriasis was associated with an increased rate of coronary artery disease. These data has not been investigated in our population. We performed a cross-sectional study analyzing data from electronic medical records of a health system in Buenos Aires. We included all patients older than 18 years diagnosed with psoriasis between January 1, 2003 and July 31, 2011 and compared them with a control group. Controls were selected randomly by strata of age and sex from the same health system in a 2:1 ratio. We determined the prevalence of cardiovascular risk factors and coronary heart disease. We analyzed the association between psoriasis and coronary artery disease by both univariate and multivariate analyzes. In total, 3 833 subjects were included (1 286 with psoriasis and 2 547 controls). The prevalence of hypertension (50% vs. 38%, p < 0.001), smoking (25% vs. 17%, p < 0.001), diabetes (12% vs. 8%, p < 0.001) and coronary artery disease (4.98% vs. 3.06%, p = 0.003) were higher in the psoriasis group compared to controls. Regardless age and the presence or absence of diabetes, hypertension or smoking, there was a significant association between coronary artery disease and psoriasis (OR 1.48, CI95% 1.04-2.11, p = 0.03). In conclusion, in this population of Buenos Aires, psoriasis patients had a higher prevalence of diabetes, hypertension, smoking, and coronary artery disease. The association between psoriasis and coronary artery disease was independent of the risk factors explored.
在以往的报告中，银屑病与冠状动脉疾病发生率增加有关。在我们的人群中尚未对这些数据进行研究。我们进行了一项横断面研究，分析来自布宜诺斯艾利斯一个卫生系统电子病历的数据。我们纳入了2003年1月1日至2011年7月31日期间所有年龄在18岁以上被诊断为银屑病的患者，并将他们与一个对照组进行比较。对照组按年龄和性别分层从同一卫生系统中以2:1的比例随机选取。我们确定了心血管危险因素和冠心病的患病率。我们通过单变量和多变量分析来分析银屑病与冠状动脉疾病之间的关联。总共纳入了3833名受试者（1286名银屑病患者和2547名对照）。银屑病组的高血压患病率（50%对38%，p<0.001）、吸烟率（25%对17%，p<0.001）、糖尿病患病率（12%对8%，p<0.001）和冠状动脉疾病患病率（4.98%对3.06%，p = 0.003）均高于对照组。无论年龄以及是否存在糖尿病、高血压或吸烟，冠状动脉疾病与银屑病之间均存在显著关联（OR 1.48，CI95% 1.04 - 2.11，p = 0.03）。总之，在布宜诺斯艾利斯的这个人群中，银屑病患者的糖尿病、高血压、吸烟和冠状动脉疾病患病率更高。银屑病与冠状动脉疾病之间的关联独立于所探究的危险因素。
