Eskitis Institute for Drug Discovery, Griffith University, Nathan, Brisbane 4111, Australia.
Mar Drugs. 2013 Oct 22;11(10):4058-82. doi: 10.3390/md11104058.
Marine natural products are a diverse, unique collection of compounds with immense therapeutic potential. This has resulted in these molecules being evaluated for a number of different disease indications including the neglected protozoan diseases, human African trypanosomiasis and Chagas disease, for which very few drugs are currently available. This article will review the marine natural products for which activity against the kinetoplastid parasites; Trypanosoma brucei brucei, T.b. rhodesiense and T. cruzi has been reported. As it is important to know the selectivity of a compound when evaluating its trypanocidal activity, this article will only cover molecules which have simultaneously been tested for cytotoxicity against a mammalian cell line. Compounds have been grouped according to their chemical structure and representative examples from each class were selected for detailed discussion.
海洋天然产物是一类具有巨大治疗潜力的多样化、独特的化合物。这导致这些分子被评估用于许多不同的疾病适应症，包括被忽视的原生动物疾病、人类非洲锥虫病和恰加斯病，目前这些疾病几乎没有可用的药物。本文将综述针对动质体寄生虫；布氏锥虫布鲁斯、T.b.罗得西亚和克氏锥虫的具有活性的海洋天然产物。由于在评估其杀锥虫活性时了解化合物的选择性非常重要，因此本文仅涵盖已同时针对哺乳动物细胞系进行细胞毒性测试的分子。化合物已根据其化学结构进行分组，并选择每类的代表性实例进行详细讨论。
