铜催化的三组分、五组分或七组分偶联反应：基于斯特雷克（Strecker）型合成法，选择合成氰甲基胺、N,N-双（氰甲基）胺和 N,N'-双（氰甲基）亚甲基二胺。
Copper-catalyzed three- five- or seven-component coupling reactions: the selective synthesis of cyanomethylamines, N,N-bis(cyanomethyl)amines and N,N'-bis(cyanomethyl)methylenediamines based on a Strecker-type synthesis.
机构信息
Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science (RIKADAI), Noda, Chiba 278-8510, Japan.
出版信息
Molecules. 2013 Oct 10;18(10):12488-99. doi: 10.3390/molecules181012488.
We have demonstrated that a cooperative catalytic system comprised of CuCl and Cu(OTf)(2) could be used to effectively catalyse the three-, five- and seven-component coupling reactions of aliphatic or aromatic amines, formaldehyde, and trimethylsilyl cyanide (TMSCN), and selectively produce in good yields the corresponding cyanomethylamines, N,N-bis(cyanomethyl)amines and N,N'-bis(cyanomethyl)methylenediamines.
我们已经证明，由 CuCl 和 Cu(OTf)(2) 组成的协同催化体系可以有效地催化脂肪族或芳香族胺、甲醛和三甲基硅基氰化物（TMSCN）的三、五和七组分偶联反应，并选择性地以良好的收率生成相应的氰甲基胺、N,N-双（氰甲基）胺和 N,N'-双（氰甲基）亚甲基二胺。
Zotero 插件