Sakaguchi Kanako, Matsuda Kazuya, Suzuki Hiromi, Yamamoto Nao, Kondo Yumi, Ando Takaaki, Koiwa Masateru, Kagawa Yumiko, Taniyama Hiroyuki
1Kazuya Matsuda, Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyodai-Midorimachi, Ebetsu, Hokkaido 069-8501, Japan.
J Vet Diagn Invest. 2013 Nov;25(6):811-5. doi: 10.1177/1040638713507447. Epub 2013 Oct 23.
Yolk sac tumors (YSTs) are rare neoplasms of germ cell origin. In humans, the tumors primarily occur in the testes or ovaries, but occasionally develop at other sites. The neoplastic cells of YSTs form many histological patterns resembling embryonal structures, and the World Health Organization classification lists 11 such patterns: reticular, macrocystic, endodermal sinus, papillary, solid, glandular-alveolar, myxomatous, sarcomatoid, polyvesicular vitelline, hepatoid, and parietal. Among domestic animals, only 2 cases of YST, which were of testicular and abdominal cavity origin, have been reported in calves. In both cases, neoplastic cells had epithelial properties and disseminated metastases in the abdomen. In the present study, the enlarged testis of a newborn calf, which was subsequently diagnosed as YST and exhibited myxomatous, reticular, and polyvesicular vitelline histological patterns, is described. There was no metastasis in this case, and histological and immunohistochemical features varied from previous cases of YST.
卵黄囊瘤（YSTs）是一种罕见的生殖细胞起源肿瘤。在人类中，该肿瘤主要发生于睾丸或卵巢，但偶尔也会在其他部位发生。卵黄囊瘤的肿瘤细胞形成许多类似于胚胎结构的组织学模式，世界卫生组织分类列出了11种此类模式：网状、大囊状、内胚窦、乳头状、实性、腺泡状、黏液瘤样、肉瘤样、多囊性卵黄囊、肝样和壁层。在家畜中，仅报道过2例犊牛的卵黄囊瘤，分别起源于睾丸和腹腔。在这两例中，肿瘤细胞均具有上皮特性，并在腹部发生了转移性扩散。在本研究中，描述了一头新生犊牛肿大的睾丸，随后被诊断为卵黄囊瘤，并表现出黏液瘤样、网状和多囊性卵黄囊组织学模式。该病例未发生转移，其组织学和免疫组化特征与先前报道的卵黄囊瘤病例有所不同。
