Mastrogianni Orthodoxia, Gbandi Emma, Orphanidis Amvrosios, Raikos Nikolaos, Goutziomitrou Evangelia, Kolibianakis Efstratios M, Tarlatzis Basil C, Goulas Antonis
Department of Forensic Medicine and Toxicology, Medical School, Aristotle University of Thessaloniki.
Drug Metab Pharmacokinet. 2014;29(2):215-8. doi: 10.2133/dmpk.dmpk-13-nt-092. Epub 2013 Oct 22.
Cytochrome P450 2B6 (CYP2B6) is responsible for the initial biotransformation of profol, an extensively metabolized intravenous anesthetic. In this study we examined the effect of the apparently functional CYP2B6 c.516G>T polymorphism on the distribution of propofol concentrations, quantified by GC/MS analysis following a single bolus dose, in the blood of 44 Greek women undergoing oocyte retrieval. Univariate analysis using age, height, weight and smoking status as covariates, as well as the Mann-Whitney non-parametric test, revealed a strong trend of association of the T allele with high propofol concentrations determined in whole blood, shortly after a single bolus dose. Propofol concentrations which were higher than one standard deviation of the mean were almost invariably associated with carriage of the T allele.
细胞色素P450 2B6（CYP2B6）负责丙泊酚（一种广泛代谢的静脉麻醉剂）的初始生物转化。在本研究中，我们检测了明显具有功能的CYP2B6 c.516G>T多态性对44名接受取卵手术的希腊女性血液中丙泊酚浓度分布的影响，丙泊酚浓度通过单次推注剂量后采用气相色谱/质谱分析进行定量。以年龄、身高、体重和吸烟状况作为协变量进行单因素分析，以及使用曼-惠特尼非参数检验，结果显示在单次推注剂量后不久，T等位基因与全血中测得的高丙泊酚浓度存在强烈的关联趋势。高于平均浓度一个标准差的丙泊酚浓度几乎总是与T等位基因的携带相关。
