Department of Preventive Medicine, Gachon University of Medicine and Science, Incheon, Korea (K-PK); the Department of Surgery, Breast and Endocrine Service, Seoul National University Bundang Hospital, Gyeonggi-do, Korea (S-WK and EK); the Departments of Preventive Medicine (SHM and SKP) and Biomedical Science (SKP), Seoul National University College of Medicine, Seoul, Korea; the Cancer Research Institute, Seoul National University, Seoul, Korea (SHM and SKP); the Cancer Policy Branch, National Cancer Control Institute, National Cancer Center, Gyeonggi-do, Korea (BP); the Division of Epidemiology and Health Index, Center for Genome Science, Korea Centers for Disease Control & Prevention, Chungcheongbuk-do, Korea (YA); the Department of Surgery, College of Medicine, University of Ulsan and Asan Medical Center, Seoul, Korea (JWL); the Department of Surgery, College of Medicine, Soonchunhyang University, Seoul, Korea (MHL); the Department of Surgery, Hallym University Sacred Heart Hospital, Anyang, Korea (LSK); the Department of Surgery, Ajou University School of Medicine, Suwon, Korea (YJ); the Department of Surgery, Inha University Hospital, Incheon, Korea (YUC); the Department of Surgery, Chonbuk National University Medical School, Jeonju, Korea (BL); and the Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (JHL).
Am J Clin Nutr. 2013 Dec;98(6):1493-501. doi: 10.3945/ajcn.112.057760. Epub 2013 Oct 23.
Soy intake is associated with a lower risk of breast cancer. However, it is unclear whether the same reduction in risk associated with high soy intake is also applicable to familial or genetic breast cancer.
The aim of this study was to assess the dietary factors among carriers and noncarriers of BRCA mutations in the Korean Hereditary Breast Cancer Study (KOHBRA).
The KOHBRA Study is an ongoing project composed of affected breast cancer patients and familial members of breast cancer cases with BRCA mutations. To assess the association between dietary diversity and breast cancer risk, an HR was estimated by comparing affected subjects with their familial nonaffected members. To assess the interaction between the combination of BRCA mutation and diet diversity, the case-only OR (COR) was estimated by comparing BRCA mutation carriers and noncarriers only in affected subjects.
Soy product intake was associated with a lower risk of breast cancer in carriers (HR: 0.39; 95% CI: 0.19, 0.79 for the highest quartile). The highest quartile of meat intake was associated with a higher risk of breast cancer regardless of BRCA mutation in carriers (HR: 1.97; 95% CI: 1.13, 3.44) and noncarriers (95% CI: 1.41; 1.12, 1.78). The associations of meat intake and soybean intake for breast cancer were more prominent in BRCA2 mutation carriers. In the analysis with only cases, the highest quartile of soy intake, but not meat intake, was associated with BRCA-related breast cancer (COR: 0.57; 95% CI: 0.36, 0.91).
Our study suggests that soy product consumption is associated with lower breast cancer risk and it had an interaction with BRCA mutation.
大豆摄入量与乳腺癌风险降低有关。然而，目前尚不清楚与高大豆摄入量相关的同样风险降低是否也适用于家族性或遗传性乳腺癌。
本研究旨在评估韩国遗传性乳腺癌研究（KOHBRA）中 BRCA 突变携带者和非携带者的饮食因素。
KOHBRA 研究是一个正在进行的项目，由乳腺癌患者及其携带 BRCA 突变的乳腺癌家族成员组成。为了评估饮食多样性与乳腺癌风险之间的关联，通过比较受影响的受试者与其家族中非受影响的成员，估计了 HR。为了评估 BRCA 突变与饮食多样性组合之间的相互作用，仅在受影响的受试者中比较 BRCA 突变携带者和非携带者，估计了病例仅的 OR（COR）。
大豆制品的摄入与携带者乳腺癌风险降低相关（HR：0.39；95%CI：0.19，0.79，最高四分位数）。无论 BRCA 突变如何，肉类摄入的最高四分位数与携带者（HR：1.97；95%CI：1.13，3.44）和非携带者（95%CI：1.41；1.12，1.78）的乳腺癌风险增加相关。肉类和大豆摄入量与乳腺癌的关联在 BRCA2 突变携带者中更为明显。在仅病例的分析中，最高四分位数的大豆摄入量与 BRCA 相关乳腺癌相关（COR：0.57；95%CI：0.36，0.91），而不是肉类摄入量。
我们的研究表明，大豆制品的摄入与乳腺癌风险降低有关，并且与 BRCA 突变存在相互作用。
