Jendryczko A, Drozdz M, Magner K
Exp Pathol. 1985;28(3):187-9. doi: 10.1016/s0232-1513(85)80007-4.
Collagen-like syndrome was induced in rats by oral hydralazine administration during 5 months. After 4 months, a subgroup of rats was shifted from the standard diet to the diet supplemented with copper (II) (60 micrograms of copper per g of pellet) as copper sulphate. A decreased serum copper concentration was noted, LE cells were observed in the blood of 75% of rats fed with standard diet. In the subgroup of copper supplemented rats, the LE cells were observed in 40% of rats only. The activity of superoxide dismutase, the antioxidative copper-dependent enzyme, was significantly lower in erythrocytes of rats fed with standard diet, than the activity in rats fed with copper supplemented diet. These results are briefly discussed.
通过连续5个月给大鼠口服肼苯哒嗪诱导其出现胶原样综合征。4个月后，将一组大鼠从标准饮食改为补充硫酸铜（每克颗粒含60微克铜）的饮食。观察到血清铜浓度降低，在喂食标准饮食的大鼠中，75%的大鼠血液中出现了狼疮细胞。在补充铜的大鼠亚组中，仅40%的大鼠出现了狼疮细胞。超氧化物歧化酶（一种依赖铜的抗氧化酶）的活性在喂食标准饮食的大鼠红细胞中显著低于喂食补充铜饮食的大鼠。对这些结果进行了简要讨论。
