Kucharz E, Dróźdź M
Folia Haematol Int Mag Klin Morphol Blutforsch. 1978;105(2):216-22.
Haematological studies were carried out in hydralazine-induced collagen-like syndrome in guinea pigs. 37.5 per cent of animals were found to be LE-positive. It was found that long-term administration of hydralazine caused a decrease of erythrocyte count, a decrease of haemoglobin concentration and a decrease of haemoglobin content in individual red blood cell as well as a decrease of a single erythrocyte volume. A significant leukopenia was shown in LE-positive subgroup of hydralazine-treated guinea pigs. The obtained results confirmed the similarity of hydralazine syndrome to systemic lupus erythematosus.
对豚鼠肼屈嗪诱导的胶原样综合征进行了血液学研究。发现37.5%的动物LE呈阳性。结果发现，长期给予肼屈嗪会导致红细胞计数减少、血红蛋白浓度降低、单个红细胞内血红蛋白含量减少以及单个红细胞体积减小。在接受肼屈嗪治疗的豚鼠的LE阳性亚组中出现了明显的白细胞减少。所得结果证实了肼屈嗪综合征与系统性红斑狼疮的相似性。
