Meyer-Rienecker H J, Jenssen H L, Mix E
Fortschr Neurol Psychiatr. 1985 Oct;53(10):363-9. doi: 10.1055/s-2007-1001981.
In brain tumors and other neurological diseases cell-mediated immune reactions to fetal brain tissue antigens (FBA), normal tissue antigen of adult brain (NTA) and tumor-associated antigens of different brain tumors (TAA) have been analysed. The detection of sensitized lymphocytes using the MEM-(macrophage-electrophoretic-mobility-) test revealed general tumor-related results applying the FBA, in some extent a cross reactivity and partly no kind of reaction. A phase-specific reactivity to normal brain antigens could not be found, only cases of multiple sclerosis produced restrictive results employing the NTA. By testing tumor-associated brain antigens different reaction types were seen: The common TAA caused a tumor-characteristic reaction; the histo-specific TAA predominantly presented a organotypic form of reaction, confined a histo-specific reaction pattern; in some cases there were found inadequate, non-corresponding reactions as well as unreactivity. With regard to different types of reaction the problems of heterogeneity of the brain tumors and the cellular immune response--i.e. a heterogeneity of 1. or 2. order--were discussed including further factors concerning several special conditions in the nervous system.
在脑肿瘤和其他神经疾病中，已经对针对胎儿脑组织抗原（FBA）、成人大脑正常组织抗原（NTA）以及不同脑肿瘤的肿瘤相关抗原（TAA）的细胞介导免疫反应进行了分析。使用MEM-（巨噬细胞电泳迁移率-）试验检测致敏淋巴细胞，结果显示，应用FBA时呈现出与肿瘤相关的一般结果，在一定程度上存在交叉反应，部分则无反应。未发现对正常脑抗原的阶段特异性反应，仅在多发性硬化症病例中，使用NTA时得出有限的结果。通过检测肿瘤相关脑抗原，观察到不同的反应类型：常见的TAA引发肿瘤特征性反应；组织特异性TAA主要呈现器官型反应形式，局限于组织特异性反应模式；在某些情况下，还发现了不充分、不对应的反应以及无反应情况。关于不同类型的反应，讨论了脑肿瘤异质性和细胞免疫反应的问题，即一阶或二阶异质性，还包括与神经系统几种特殊情况相关的其他因素。
