Laboratoire de Chimie Organique, Service de Chimie et PhysicoChimie Organiques, Université Libre de Bruxelles, Avenue F. D. Roosevelt 50, CP160/06, 1050 Brussels, Belgium.
Nat Prod Rep. 2013 Dec;30(12):1467-89. doi: 10.1039/c3np70071b.
Copper-catalyzed Ullmann-Goldberg-type cross-coupling reactions have undergone nothing short of a renaissance over the last decade and an impressive number of procedures are now available for the formation of C-N, C-O and C-S bonds with remarkable efficiencies and surgical precision. These reactions have been recently integrated into natural product synthesis, which clearly resulted in the emergence of new retrosynthetic paradigms and bond disconnections. The impact of copper-catalyzed cross-coupling reactions in natural product synthesis will be overviewed in this article with an emphasis on the evolution of strategies due to copper catalysis, mostly by comparison with alternative tactics and their relative efficiencies.
在过去的十年中，铜催化的乌尔曼-戈尔德伯格型交叉偶联反应经历了复兴，现在已经有了大量的方法可用于高效、精确地形成 C-N、C-O 和 C-S 键。这些反应最近已经被整合到天然产物合成中，这显然导致了新的反合成范例和键的切断的出现。本文将综述铜催化交叉偶联反应在天然产物合成中的应用，重点介绍由于铜催化而导致的策略演变，主要通过与替代策略及其相对效率进行比较。
