硫酸氢盐/六氟异丙醇缔合催化芳烃与偶氮二甲酸酯的直接胺化反应
Direct Amination of Arenes with Azodicarboxylates Catalyzed by Bisulfate Salt/HFIP Association.
作者信息
Tang Ren-Jin, Retailleau Pascal, Milcent Thierry, Crousse Benoit
机构信息
Faculté de Pharmacie, UMR 8076, BioCIS, Univ. Paris-Sud, CNRS, Université Paris-Saclay, 92290 Châtenay-Malabry, France.
Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Univ. Paris-Sud, Université Paris-Saclay, 1, avenue de la Terrasse, 91198 Gif-sur-Yvette, France.
出版信息
ACS Omega. 2019 May 22;4(5):8960-8966. doi: 10.1021/acsomega.9b00781. eCollection 2019 May 31.
A mild and efficient amination of arenes with azodicarboxylates using potassium bisulfate (KHSO) as the catalyst in 1,1,1,3,3,3-hexafluoro-2-propanol has been developed. This protocol allowed the amination of a broad range of arenes leading to corresponding hydrazides in good to excellent yields.
已开发出一种温和且高效的方法，在1,1,1,3,3,3-六氟-2-丙醇中使用硫酸氢钾（KHSO）作为催化剂，使芳烃与偶氮二羧酸酯进行胺化反应。该方法可实现多种芳烃的胺化反应，以良好至优异的产率得到相应的酰肼。
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