Department of Chemical and Biological Engineering, Kemivägen 10, Chalmers University of Technology, SE412 96 Gothenburg, Sweden.
Sci Rep. 2013 Oct 24;3:3041. doi: 10.1038/srep03041.
Cancer cells can have a broad scope of proliferation rates. Here we aim to identify the molecular mechanisms that allow some cancer cell lines to grow up to 4 times faster than other cell lines. The correlation of gene expression profiles with the growth rate in 60 different cell lines has been analyzed using several genome-scale biological networks and new algorithms. New possible regulatory feedback loops have been suggested and the known roles of several cell cycle related transcription factors have been confirmed. Over 100 growth-correlated metabolic sub-networks have been identified, suggesting a key role of simultaneous lipid synthesis and degradation in the energy supply of the cancer cells growth. Many metabolic sub-networks involved in cell line proliferation appeared also to correlate negatively with the survival expectancy of colon cancer patients.
癌细胞的增殖速度范围很广。在这里，我们旨在确定使某些癌细胞系的生长速度比其他细胞系快 4 倍的分子机制。使用几种基因组规模的生物网络和新算法分析了 60 种不同细胞系的基因表达谱与生长速度之间的相关性。提出了新的可能的调节反馈回路，并证实了几个细胞周期相关转录因子的已知作用。已经鉴定出 100 多个与生长相关的代谢子网络，这表明脂质合成和降解的同时进行在癌细胞生长的能量供应中起着关键作用。涉及细胞系增殖的许多代谢子网络似乎也与结肠癌患者的预期寿命呈负相关。
