癌症基因组的演变。
Evolution of the cancer genome.
机构信息
Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK.
出版信息
Nat Rev Genet. 2012 Nov;13(11):795-806. doi: 10.1038/nrg3317. Epub 2012 Oct 9.
Abstract
The advent of massively parallel sequencing technologies has allowed the characterization of cancer genomes at an unprecedented resolution. Investigation of the mutational landscape of tumours is providing new insights into cancer genome evolution, laying bare the interplay of somatic mutation, adaptation of clones to their environment and natural selection. These studies have demonstrated the extent of the heterogeneity of cancer genomes, have allowed inferences to be made about the forces that act on nascent cancer clones as they evolve and have shown insight into the mutational processes that generate genetic variation. Here we review our emerging understanding of the dynamic evolution of the cancer genome and of the implications for basic cancer biology and the development of antitumour therapy.
摘要
大规模平行测序技术的出现使得对癌症基因组的描述达到了前所未有的分辨率。对肿瘤突变景观的研究为癌症基因组进化提供了新的见解，揭示了体细胞突变、克隆对其环境的适应和自然选择之间的相互作用。这些研究表明了癌症基因组异质性的程度，使人们能够推断出在新出现的癌症克隆进化过程中起作用的力量，并深入了解产生遗传变异的突变过程。在这里，我们回顾了我们对癌症基因组动态进化的认识，以及对癌症生物学基础和抗肿瘤治疗发展的影响。
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