Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York.
J Surg Oncol. 2014 Jan;109(1):23-7. doi: 10.1002/jso.23451. Epub 2013 Oct 24.
Gastrointestinal stromal tumor (GIST) is the most common sarcoma of the intestinal tract. Improvements in understanding the molecular pathogenesis of GIST have resulted in novel treatment strategies combining surgery with tyrosine kinase inhibitors (TKIs). Metastasectomy in carefully selected patients who have stable or responsive disease on imatinib should be considered in the multidisciplinary setting. We review existing data on surgical cytoreduction in metastatic GIST while on targeted therapy and compare outcomes with either treatment alone.
胃肠道间质瘤(GIST)是最常见的肠道肉瘤。对 GIST 分子发病机制的认识的提高,导致了将手术与酪氨酸激酶抑制剂(TKIs)相结合的新的治疗策略。对于在伊马替尼治疗下疾病稳定或有反应的精心选择的患者,应考虑在多学科环境下进行转移灶切除术。我们回顾了靶向治疗时转移性 GIST 手术减瘤的现有数据,并将其与单独治疗的结果进行了比较。