The Korea Central Cancer Registry, Division of Cancer Registration and Surveillance, National Cancer Center, Goyang, Korea.
Cancer Res Treat. 2013 Sep;45(3):162-71. doi: 10.4143/crt.2013.45.3.162. Epub 2013 Sep 30.
Although the cancer stage at diagnosis is the most important prognostic factor for patients' survival, there are few population-based estimates of stage-specific survival outcome, especially in Asian countries. Our study aims to estimate stage-specific survival for Korean patients.
We analyzed the Korea National Cancer Incidence Database data on 626,506 adult patients aged ≥ 20 years, who were diagnosed between 2006 and 2010 with stomach, colorectal, liver, lung, breast, cervix, prostate, and thyroid cancers. Patients were followed up to December 2011, and the 5-year relative survival rates (RSRs) were calculated for gender and age group by Surveillance, Epidemiology, and End Results (SEER) stage at diagnosis.
The 5-year RSRs for all localized-stage cancers, except for lung and liver, exceeded 90% with that for thyroid cancer being the highest at 100.4%. These values for distant stage liver, lung, and stomach cancers were very dismal at 2.5%, 4.8%, and 5.5%, respectively, while it was 69.1% for thyroid cancer, and was in the range of 18.3-36.4% for colorectal, cervix, breast and prostate cancers. Overall, the 5-year RSRs for all cancer types decreased with aging across all the disease stages with exception of prostate cancer, which suggests biologic difference in these cancer types in a young age group. When compared with US SEER data, Korean patients had better stage-specific survival rates for stomach, colorectal, liver, and cervical cancers.
Korean cancer patients showed relatively favorable stage distribution and 5-year RSRs, which suggests potential contribution of the national cancer screening program.
尽管癌症诊断时的分期是影响患者生存的最重要的预后因素，但针对特定分期的生存结果，尤其是在亚洲国家，仅有少数基于人群的估计数据。本研究旨在评估韩国患者的特定分期的生存情况。
我们分析了 2006 年至 2010 年间年龄≥20 岁的 626,506 例成人患者的韩国国家癌症发病率数据库数据，这些患者被诊断患有胃癌、结直肠癌、肝癌、肺癌、乳腺癌、宫颈癌、前列腺癌和甲状腺癌。对患者进行了随访，随访截至 2011 年 12 月，按诊断时的监测、流行病学和最终结果（SEER）分期，计算了不同性别和年龄组的 5 年相对生存率（RSR）。
除肺癌和肝癌外，所有局限性癌症的 5 年 RSR 均超过 90%，其中甲状腺癌最高，为 100.4%。远处分期的肝癌、肺癌和胃癌的 5 年 RSR 非常低，分别为 2.5%、4.8%和 5.5%，而甲状腺癌为 69.1%，结直肠癌、宫颈癌、乳腺癌和前列腺癌的范围为 18.3-36.4%。总体而言，除前列腺癌外，所有癌症类型的 5 年 RSR 随着各疾病分期的年龄增长而降低，这表明在年轻人群中这些癌症类型存在生物学差异。与美国 SEER 数据相比，韩国患者的胃癌、结直肠癌、肝癌和宫颈癌的特定分期生存结果较好。
韩国癌症患者的分期分布和 5 年 RSR 相对较好，这表明国家癌症筛查计划可能发挥了作用。
