Kim Bo Ri, Lee Dong Ho, Shim Hyun Ik, Kim Jee Woo, Park Sanghyun, Shin Cheol Min, Han Kyungdo, Youn Sang Woong
Department of Dermatology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
Ann Dermatol. 2022 Jun;34(3):191-199. doi: 10.5021/ad.2022.34.3.191. Epub 2022 May 20.
Although patients with psoriasis have an increased risk of cancers, little is known about the risk of psoriasis in cancer patients.
We aimed to comparatively analyze the incidence and risk factors of psoriasis in gastric cancer patients who underwent gastrectomy and in the general population.
A nationwide retrospective cohort of 52,608 gastric cancer survivors (2007~2015) was compared to 123,438 matched controls from the general population to estimate the incidence and hazard ratio (HR) of new-onset psoriasis. We also calculated the HRs for psoriasis according to adjuvant cancer treatment, obesity, and vitamin B supplementation in gastric cancer survivors.
During a mean follow-up of 6.85 years, 645 of the 52,608 gastric cancer patients developed psoriasis, while 1,806 in the 123,438 matched control group developed psoriasis. Gastric cancer patients had a decreased risk of psoriasis (HR, 0.86; 95% confidence interval, 0.79~0.94), especially those who underwent subtotal gastrectomy. We found that vitamin B supplementation for more than 3 years had an additive effect on decreasing the risk of psoriasis in gastric cancer patients who underwent subtotal gastrectomy. Total gastrectomy, radio/chemotherapy, and obesity did not affect the risk of psoriasis in gastric cancer survivors.
The incidence of psoriasis is slightly lower in gastric cancer survivors than in the general population. Our results suggest that the development of psoriasis may be reduced by removing the source of systemic inflammation caused by infection through subtotal gastrectomy in gastric cancer survivors.
虽然银屑病患者患癌症的风险增加，但关于癌症患者患银屑病的风险却知之甚少。
我们旨在比较分析接受胃切除术的胃癌患者和普通人群中银屑病的发病率及危险因素。
将全国范围内52608名胃癌幸存者（2007年至2015年）的回顾性队列与来自普通人群的123438名匹配对照进行比较，以估计新发银屑病的发病率和风险比（HR）。我们还根据胃癌幸存者的辅助癌症治疗、肥胖和维生素B补充情况计算了银屑病的HR。
在平均6.85年的随访期间，52608名胃癌患者中有645人患银屑病，而123438名匹配对照组中有1806人患银屑病。胃癌患者患银屑病的风险降低（HR，0.86；95%置信区间，0.79至0.94），尤其是那些接受胃次全切除术的患者。我们发现，补充维生素B超过3年对降低接受胃次全切除术的胃癌患者患银屑病的风险有累加效应。全胃切除术、放疗/化疗和肥胖对胃癌幸存者患银屑病的风险没有影响。
胃癌幸存者中银屑病的发病率略低于普通人群。我们的结果表明，通过胃次全切除术消除胃癌幸存者中由感染引起的全身炎症来源，可能会降低银屑病的发生。
