Department of Anaeasthesiology, Jahrom University of Medical Sciences, Jahrom, Iran.
Korean J Pain. 2013 Oct;26(4):379-86. doi: 10.3344/kjp.2013.26.4.379. Epub 2013 Oct 2.
Shivering related to spinal anesthesia may interfere with monitoring and is uncomfortable. The aim of the present study was to investigate low-dose intrathecal meperidine for the prevention of shivering after induction of spinal anesthesia in parturients with cesarean section.
This was a prospective randomized, double-blind, placebo-controlled trial including 100 parturients, of American Society of Anesthesiologists (ASA) physical status I or II, scheduled for elective cesarean section under spinal anesthesia who were randomly assigned to a meperidine (0.2 mg/kg) plus hyperbaric lidocaine (5%, 75 mg, n = 50; group M) group or a placebo plus hyperbaric lidocaine (5%, 75 mg, n = 50; group L) group. Demographic and surgical data, adverse events, and the mean intensity for each parturient were assessed during the entire study period by a blinded observer.
There were no significant differences between the two study groups regarding the demographic and surgical data (P > 0.05). The incidence of shivering during the entire study period significantly decreased in the group of parturients who received intrathecal meperidine (P = 0.04). There were no significant differences in nausea and vomiting between the two groups.
Low-dose intrathecal meperidine (10 mg) is safe and effective in reducing the incidence and severity of shivering associated with spinal anesthesia in parturients with cesarean section.
脊髓麻醉相关的寒战会干扰监测，且令人不适。本研究旨在探讨鞘内给予小剂量哌替啶预防剖宫产产妇脊髓麻醉后寒战。
这是一项前瞻性随机双盲安慰剂对照试验，纳入了 100 例行择期剖宫产术且美国麻醉医师协会（ASA）分级为 I 或 II 级的产妇，随机分为哌替啶（0.2mg/kg）加布比卡因（5%，75mg，n=50；M 组）或安慰剂加布比卡因（5%，75mg，n=50；L 组）组。由一名盲法观察者在整个研究期间评估产妇的人口统计学和手术数据、不良事件以及每位产妇的平均寒战强度。
两组产妇的人口统计学和手术数据无显著差异（P＞0.05）。鞘内给予哌替啶可显著降低产妇在整个研究期间的寒战发生率（P=0.04）。两组产妇恶心呕吐的发生率无显著差异。
鞘内给予小剂量哌替啶（10mg）可安全有效降低剖宫产产妇脊髓麻醉后寒战的发生率和严重程度。
