Verstraeten A S, Verbrugghe W, Wuyts W
Department of Intensive Care Medicine, Antwerp University Hospital, Edegem.
Acta Clin Belg. 2013 May-Jun;68(3):240-4. doi: 10.2143/ACB.3276.
We describe the case of a man with known dermatomyositis who presented with a dry cough and who early after admission rapidly evolved to respiratory insufficiency. Based on pathological and radiological findings, the diagnosis of diffuse alveolar damage was made. Postmortem examination also revealed infection with yeast, Torulopsis glabrata. Polymyositis (PM) and dermatomyositis (DM) are both auto-immune diseases, which are characterised by the presence of auto-antibodies and tissue-inflammation, mainly involving the muscles. Patients with PM/DM may have pulmonary complications, often responsible for higher morbidity and mortality. Interstitial lung disease can present itself in different shapes and forms (bronchiolitis obliterans organising pneumonia, non-specific organising pneumonia, usual interstitial pneumonia, acute interstitial pneumonia) and the diagnosis is made based on the combination of pathological examination and radiological findings.
我们描述了一例已知患有皮肌炎的男性病例，该患者出现干咳，入院后不久迅速发展为呼吸功能不全。根据病理和影像学检查结果，诊断为弥漫性肺泡损伤。尸检还发现感染了光滑念珠菌酵母。多发性肌炎（PM）和皮肌炎（DM）均为自身免疫性疾病，其特征是存在自身抗体和组织炎症，主要累及肌肉。PM/DM患者可能出现肺部并发症，常常导致更高的发病率和死亡率。间质性肺疾病可呈现不同的形态（闭塞性细支气管炎机化性肺炎、非特异性机化性肺炎、普通间质性肺炎、急性间质性肺炎），诊断基于病理检查和影像学检查结果的综合判断。
