1Department of Clinical Biochemistry, College of Laboratory Diagnostic Medicine, Dalian Medical University, Dalian, China.
Int Rev Immunol. 2014 Jan;33(1):54-66. doi: 10.3109/08830185.2013.834897. Epub 2013 Oct 24.
The C-type lectins DC-SIGN, DC-SIGNR and LSECtin are encoded by the lectin gene cluster on chromosome 19p13.3 and perform cell-adhesion and pathogen recognition functions on dendritic cells, liver cells and lymph node sinusoidal endothelial cells. DC-SIGN and DC-SIGNR share similar overall gene and protein molecule structures, and they exhibit high affinity for high-mannose carbohydrates. LSECtin, a Ca2+-dependent C-type lectin, interacts with mannose, NAcGlc and fucose. These lectins allow pathogen recognition (e.g., viruses, bacteria and allergens) and cell adhesion for dendritic and endothelial cells in different tissues, which may enhance the infection and facilitate the spread of those pathogens. A better understanding of these lectins may yield information about how pathogens are captured by particular cells and how they spread in different tissues. These studies would provide more detail about the physiopathological mechanisms of viral and bacterial infections and may also lead to new strategies to treat or prevent infections.
C 型凝集素 DC-SIGN、DC-SIGNR 和 LSECtin 由染色体 19p13.3 上的凝集素基因簇编码，在树突状细胞、肝细胞和淋巴结窦内皮细胞上发挥细胞黏附作用和病原体识别功能。DC-SIGN 和 DC-SIGNR 具有相似的总体基因和蛋白分子结构，对高甘露糖碳水化合物具有高亲和力。LSECtin 是一种 Ca2+依赖性 C 型凝集素，与甘露糖、NAcGlc 和岩藻糖相互作用。这些凝集素允许树突状细胞和内皮细胞在不同组织中识别病原体（例如病毒、细菌和过敏原）并进行细胞黏附，这可能会增强感染并促进这些病原体的传播。更好地了解这些凝集素可以提供有关病原体如何被特定细胞捕获以及它们如何在不同组织中传播的信息。这些研究将更详细地了解病毒和细菌感染的生理病理机制，并可能为治疗或预防感染提供新策略。
