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MUC1 在免疫学中的研究现状与展望。

The research status and prospects of MUC1 in immunology.

机构信息

Department of Histology & Embryology, Xiangya School of Medicine, Central South University, ChangSha, China.

Department of gynaecology, Xinjiang Cancer Hospital, Xinjiang Medical University, Urumqi, Xinjiang, China.

出版信息

Hum Vaccin Immunother. 2023 Dec 31;19(1):2172278. doi: 10.1080/21645515.2023.2172278. Epub 2023 Feb 6.

Abstract

In immune processes, molecular - molecular interactions are complex. As MUC1 often appears to be an important molecule in inflammation and tumor immunity, it is necessary to summarize the leading countries, authors, journals, and the cooperation among these entities and, most importantly, to determine the main research directions related to MUC1 in this field and the associated research frontiers. A total of 3,397 related studies published from 2012-2021 were retrieved from the Web of Science core database. The search strategy is TS= (MUC1 OR Mucin-1) refined by WEB OF SCIENCE CATEGORY (IMMUNOLOGY) AND [excluding] PUBLICATION YEARS: (2022) AND DOCUMENT TYPES: (ARTICLE OR REVIEW) AND LANGUAGES: (ENGLISH) AND WEB OF SCIENCE INDEX: (Web of Science Core Collection. SCI), with a timespan of 2012 to 2021. Documented bibliometric visual analysis was performed by CiteSpace and VOSviewer. The number of studies has increased every year. There are 1,982 articles and 1,415 reviews from 89 countries and regions, 3,722 organizations, 1,042 journals, and 17,948 authors. The United States, China, and Germany are the major countries producing publications on this issue. The most published author is Finn OJ and the most influential author is June CH. The key words "chimeric antigen receptor" and "T-cell" highlight the current hot spots and future trends in this field. Research on MUC1 in the field of immunology is still evolving. Through the bibliometric analysis of the existing publications, the current research hotspots and future development trends in this field can be obtained.

摘要

在免疫过程中,分子-分子相互作用非常复杂。由于 MUC1 似乎经常是炎症和肿瘤免疫中的重要分子,因此有必要总结主要国家、作者、期刊以及这些实体之间的合作情况,最重要的是,确定该领域与 MUC1 相关的主要研究方向和相关研究前沿。从 Web of Science 核心数据库中检索到 2012 年至 2021 年期间发表的 3397 篇相关研究。搜索策略是通过 WEB OF SCIENCE CATEGORY(IMMUNOLOGY)和[排除]PUBLICATION YEARS:(2022)和 DOCUMENT TYPES:(ARTICLE OR REVIEW)和 LANGUAGES:(ENGLISH)和 WEB OF SCIENCE INDEX:(Web of Science Core Collection. SCI)对 TS=(MUC1 或 Mucin-1)进行细化,时间跨度为 2012 年至 2021 年。通过 CiteSpace 和 VOSviewer 对文献计量学可视化分析进行记录。每年的研究数量都在增加。来自 89 个国家和地区、3722 个组织、1042 种期刊和 17948 位作者的论文数量为 1982 篇,综述为 1415 篇。在这个问题上发表文献的主要国家是美国、中国和德国。发表文献最多的作者是 Finn OJ,最有影响力的作者是 June CH。关键词“嵌合抗原受体”和“T 细胞”突出了该领域当前的热点和未来趋势。免疫学领域对 MUC1 的研究仍在不断发展。通过对现有文献的计量分析,可以获得该领域当前的研究热点和未来的发展趋势。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcf7/10012890/aa8ef343031e/KHVI_A_2172278_F0001_OC.jpg

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