National Key Laboratory of Plant Molecular Genetics, CAS Key Laboratory of Synthetic Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 300 Fenglin Road, Shanghai 200032, China.
Trends Microbiol. 2013 Dec;21(12):652-9. doi: 10.1016/j.tim.2013.09.009. Epub 2013 Oct 21.
Energy-coupling factor (ECF) transporters form a new family of ATP-binding cassette (ABC) transporters and are widely used by prokaryotes to take up micronutrients from the environment. Instead of using the periplasmic solute-binding proteins (SBPs), ECF transporters use the membrane S proteins for substrate capture and translocation. In this review, we will focus on structural advances that have been made regarding how substrates are recognized by ECF transporters and possible transport mechanisms employed by the ECF transporters.
能量偶联因子（ECF）转运蛋白形成了一个新的 ATP 结合盒（ABC）转运蛋白家族，被原核生物广泛用于从环境中摄取微量元素。ECF 转运蛋白不使用周质溶质结合蛋白（SBPs），而是使用膜 S 蛋白进行底物捕获和转运。在这篇综述中，我们将重点介绍关于 ECF 转运蛋白如何识别底物的结构进展，以及 ECF 转运蛋白可能采用的运输机制。
