University of Kansas Alzheimer's Disease Center, 4350 Shawnee Mission Parkway, MS 6002 Fairway, KS 66205, USA.
University of Kansas School of Medicine, Kansas City, KS, USA.
J Clin Neurosci. 2014 Mar;21(3):536-7. doi: 10.1016/j.jocn.2013.07.001. Epub 2013 Oct 22.
Lumbar puncture for testing of Alzheimer's disease pathophysiology for diagnostic confirmation is likely to become more common in the coming years. Minimizing adverse effects from this testing will be essential for clinical practice. Small bore, atraumatic needles reduce the occurrence of post-lumbar puncture headache (PLPH). Our goal was to extend this recommendation specifically to a well-characterized aging population. We assessed PLPH in the Alzheimer's Disease Neuroimaging Initiative cohort and found that PLPH occurrence was reduced only when using a 24 gauge atraumatic needle. We recommend that lumbar punctures for clinical and research purposes in Alzheimer's disease be conducted with 24 gauge atraumatic needles.
腰椎穿刺用于检测阿尔茨海默病的病理生理学以进行诊断确认，在未来几年可能会变得更加普遍。为了临床实践，将这种检测的不良反应降到最低至关重要。小口径、无创伤的针可减少腰椎穿刺后头痛 (PLPH) 的发生。我们的目标是将这一建议特别扩展到一个特征明确的老年人群体。我们在阿尔茨海默病神经影像学倡议队列中评估了 PLPH，发现只有使用 24 号无创伤针时才会降低 PLPH 的发生。我们建议在阿尔茨海默病的临床和研究目的中进行腰椎穿刺时使用 24 号无创伤针。
