进展性多发性硬化症患者外周血中表达穿孔素的 CD56dim NK 细胞增加。
Circulating CD56dim NK cells expressing perforin are increased in progressive multiple sclerosis.
机构信息
Institute of Neurology, Catholic University, Rome, Italy.
出版信息
J Neuroimmunol. 2013 Dec 15;265(1-2):124-7. doi: 10.1016/j.jneuroim.2013.10.004. Epub 2013 Oct 12.
In this study we evaluated the percentages of CD3(-)CD56(bright), CD3(-)CD56(dim), CD3(-)CD56(bright)perforin(+) and CD3(-)CD56(dim)perforin(+) Natural Killer (NK) cells in peripheral blood from untreated secondary progressive (SP) and primary progressive (PP) multiple sclerosis (MS) patients and age and sex matched healthy subjects. Both PPMS patients and SPMS patients showed increased percentages of circulating CD3(-)CD56(dim)perforin(+) NK cells than healthy subjects. The increased percentage of CD3(-)CD56(dim) NK cells expressing perforin in patients affected by the progressive forms of MS suggests a possible role of this NK cell subpopulation in the pathogenesis of the disease.
在这项研究中，我们评估了未经治疗的继发进展型（SP）和原发进展型（PP）多发性硬化症（MS）患者外周血中 CD3(-)CD56(bright)、CD3(-)CD56(dim)、CD3(-)CD56(bright)穿孔素(+)和 CD3(-)CD56(dim)穿孔素(+)自然杀伤 (NK) 细胞的百分比，并与年龄和性别匹配的健康受试者进行了比较。PPMS 患者和 SPMS 患者的循环 CD3(-)CD56(dim)穿孔素(+)NK 细胞百分比均高于健康受试者。在进展型 MS 患者中，表达穿孔素的 CD3(-)CD56(dim)NK 细胞的百分比增加，提示该 NK 细胞亚群可能在疾病发病机制中发挥作用。
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