Institute of Neurology, Department of Neurosciences, Catholic University, Rome, Italy.
J Neuroimmunol. 2011 Dec 15;240-241:137-41. doi: 10.1016/j.jneuroim.2011.09.002. Epub 2011 Oct 15.
Relapsing-remitting multiple sclerosis (RRMS), secondary progressive (SP)MS and primary progressive (PP)MS patients showed higher percentages of circulating CD8+CD56-perforin+ T cells than controls whereas only relapsing RRMS and PPMS patients showed higher perforin expression in CD8+CD56- T cells than controls. MS patients with EDSS ≥3 showed higher percentage of CD8+CD56-perforin+ T cells than patients with EDSS <3 and controls whereas patients with EDSS <3 showed higher percentage of this T cell subpopulation than controls. Our data show that MS is characterized by a dysregulation of CD8+CD56-perforin+ T cells that may play a role in the development of disability.
复发缓解型多发性硬化症（RRMS）、继发进展型（SP）MS 和原发进展型（PP）MS 患者的循环 CD8+CD56-穿孔素+T 细胞比例高于对照组，而只有复发 RRMS 和 PPMS 患者的 CD8+CD56-T 细胞中穿孔素表达高于对照组。EDSS≥3 的 MS 患者的 CD8+CD56-穿孔素+T 细胞比例高于 EDSS<3 的患者和对照组，而 EDSS<3 的患者的该 T 细胞亚群比例高于对照组。我们的数据表明，MS 存在 CD8+CD56-穿孔素+T 细胞的失调，这可能在残疾的发展中起作用。
