Department of Surgery, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.
Department of Surgery, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ, USA.
Am J Surg. 2014 Jan;207(1):78-83. doi: 10.1016/j.amjsurg.2013.04.010. Epub 2013 Oct 21.
The aims of this study were to create a model of peritoneal carcinomatosis in patients with gastric cancer and to evaluates outcomes in patients with gastric cancer treated using surgery and hyperthermic intraperitoneal chemotherapy (HIPEC).
A single-institution cohort of patients with gastric cancer was analyzed according to the development of gastric cancer with peritoneal carcinomatosis (GCPC). Variables were evaluated using regression analysis. Kaplan-Meier analysis was used to evaluate outcomes after surgical resection, cytoreductive surgery, and HIPEC.
Age ≤60 years and local tumor stage (T3/T4) were significantly associated with GCPC (odds ratio, 3.95 and 3.94, respectively). Thirty-six-month survival was 57% for patients without peritoneal disease and 39% for patients with GCPC. There was no significant trend of improved survival after surgical management or HIPEC.
Age ≤60 years and T3/T4 tumor stage are risk factors for GCPC. Intermediate-term survival of patients with GCPC treated with surgical resection or cytoreductive surgery and HIPEC was not improved, though future research should address the possible benefits of aggressive approaches to the treatment of GCRC.
本研究旨在建立胃癌伴腹膜转移患者的模型，并评估胃癌患者接受手术和腹腔热灌注化疗（HIPEC）治疗的结果。
根据胃癌伴腹膜转移（GCPC）的发展情况，对单中心队列的胃癌患者进行分析。采用回归分析评估变量。采用 Kaplan-Meier 分析评估手术切除、减瘤手术和 HIPEC 后的结果。
年龄≤60 岁和局部肿瘤分期（T3/T4）与 GCPC 显著相关（比值比分别为 3.95 和 3.94）。无腹膜疾病患者的 36 个月生存率为 57%，而 GCPC 患者为 39%。手术治疗或 HIPEC 后生存无明显改善趋势。
年龄≤60 岁和 T3/T4 肿瘤分期是 GCPC 的危险因素。尽管未来的研究应该解决积极治疗 GCRC 的可能益处，但接受手术切除或减瘤手术和 HIPEC 治疗的 GCPC 患者的中期生存率并未提高。
