Department of Pharmacology, College of Medicine, Gachon University, Incheon, Korea.
Neurodegener Dis. 2014;13(2-3):99-102. doi: 10.1159/000355261. Epub 2013 Oct 23.
Alzheimer's disease (AD) is an irreversible neurodegenerative disease, still lacking proper clinical treatment. Therefore, many researchers have focused on the possibility of therapeutic use of stem cells for AD. Adipose-derived stem cells (ASCs), mesenchymal stem cells (MSCs) isolated from adipose tissue, are well known for their pluripotency and their ability to differentiate into multiple tissue types and have immune modulatory properties similar to those of MSCs from other origins. Because of their biological properties, ASCs can be considered for cell therapy and neuroregeneration. Our recent results clearly showed the therapeutic potential of these cells after transplantation into Tg2576 mice (an AD mouse model). Intravenously or intracerebrally transplanted human ASCs (hASCs) greatly improved the memory impairment and the neuropathology, suggesting that hASCs have a high therapeutic potential for AD.
阿尔茨海默病（AD）是一种不可逆转的神经退行性疾病，目前仍缺乏适当的临床治疗方法。因此，许多研究人员都关注干细胞治疗 AD 的可能性。脂肪来源的干细胞（ASCs）是从脂肪组织中分离出来的间充质干细胞，因其多能性和分化为多种组织类型的能力以及具有类似于其他来源的间充质干细胞的免疫调节特性而闻名。由于其生物学特性，ASCs 可用于细胞治疗和神经再生。我们最近的研究结果清楚地表明，这些细胞在移植到 Tg2576 小鼠（AD 小鼠模型）后具有治疗潜力。静脉内或脑内移植人 ASCs（hASCs）可显著改善记忆障碍和神经病理学，表明 hASCs 对 AD 具有很高的治疗潜力。
