Department of Clinical Medicine, University of Tromsø, Tromsø, Norway.
Eur Neurol. 2013;70(5-6):340-8. doi: 10.1159/000353701. Epub 2013 Oct 22.
BACKGROUND/AIMS: Albuminuria and carotid atherosclerosis are predictors of cardiovascular disease and potential predictors of cognitive decline. Our aim was to study whether albuminuria was an early predictor of cognitive function independent of carotid atherosclerosis in a general population.
The study population comprised 1,577 adults without self-reported stroke. In 1994 and 2007 all were screened for cardiovascular risk factors, urinary albumin-creatinine ratio (ACR), carotid intima-media thickness and carotid total plaque area (TPA). Endpoints were neuropsychological test results in 2007 from the digit symbol test, the finger-tapping test, the Mini Mental Status Examination and the 12-word test parts 1 and 2. Multivariate linear regression was used to assess associations.
Higher ACR, ΔACR, intima-media thickness, TPA and ΔTPA independently predicted a lower score on the digit symbol test. Higher ΔACR and ΔTPA predicted a lower score on the finger-tapping test. Higher TPA predicted a lower score on the 12-word test part 1 (immediate recall). Smoking predicted lower scores on the digit symbol and finger-tapping tests independent of albuminuria and carotid atherosclerosis.
Our results suggest that albuminuria, carotid atherosclerosis and smoking are independent predictors of executive function and motor tempo.
背景/目的：蛋白尿和颈动脉粥样硬化是心血管疾病的预测因素，也是认知能力下降的潜在预测因素。我们的目的是研究在一般人群中，蛋白尿是否是独立于颈动脉粥样硬化的认知功能的早期预测因素。
研究人群包括 1577 名无自述中风的成年人。在 1994 年和 2007 年，所有人都接受了心血管危险因素、尿白蛋白/肌酐比值（ACR）、颈动脉内膜中层厚度和颈动脉总斑块面积（TPA）的筛查。终点是 2007 年来自数字符号测试、指敲测试、简易精神状态检查和 12 字测试第 1 部分和第 2 部分的神经心理学测试结果。使用多元线性回归来评估关联。
较高的 ACR、ΔACR、内膜中层厚度、TPA 和 ΔTPA 独立预测数字符号测试得分较低。较高的 ΔACR 和 ΔTPA 预测指敲测试得分较低。较高的 TPA 预测 12 字测试第 1 部分（即时回忆）得分较低。吸烟独立于蛋白尿和颈动脉粥样硬化预测数字符号和指敲测试得分较低。
我们的结果表明，蛋白尿、颈动脉粥样硬化和吸烟是执行功能和运动速度的独立预测因素。
