Kovach Christine R, Woods Diana Lynn, Devine Elizabeth C, Logan Brent R, Raff Hershel
Res Gerontol Nurs. 2014 Mar-Apr;7(2):56-65. doi: 10.3928/19404921-20131018-01. Epub 2013 Oct 24.
This article discusses the use of biobehavioral measures as outcomes for health care intervention studies. Effect size (ES) values for salivary cortisol and observation-based measures of pain and agitation were examined. Effects pre to post treatment were assessed separately for nursing home residents with and without acute psychotic symptoms. This study revealed large positive effects on both pain and agitation measures in the group with acute psychotic symptoms and small-to-medium positive effects on these same measures in the group without acute psychotic symptoms. In both of these groups, the ES values were not consistently positive on the cortisol measures. Prior to determining whether a measure can be used to estimate minimum clinically important differences, it is essential to consider if the biomarker will be responsive to therapy in the populations and contexts being studied.
本文讨论了使用生物行为测量作为医疗保健干预研究的结果。研究了唾液皮质醇的效应大小（ES）值以及基于观察的疼痛和激越测量值。分别对有和没有急性精神病症状的养老院居民治疗前后的效果进行了评估。这项研究表明，有急性精神病症状的组在疼痛和激越测量方面有较大的积极效果，而没有急性精神病症状的组在这些相同测量方面有小到中等的积极效果。在这两组中，皮质醇测量的ES值并非始终为正。在确定一种测量方法是否可用于估计最小临床重要差异之前，必须考虑该生物标志物在正在研究的人群和背景中是否会对治疗产生反应。
