Walker P R, Papouchado M, James M A, Clarke L M
Pacing Clin Electrophysiol. 1985 Nov;8(6):900-2. doi: 10.1111/j.1540-8159.1985.tb05910.x.
Flecainide acetate is a recently introduced, class 1 antiarrhythmic agent that is highly effective in the treatment of ventricular and atrioventricular/nodal reentrant tachycardias. Although both intravenous and orally administered flecainide are known to cause an increase in the pacing threshold, an abrupt and potentially lethal rise in threshold causing failure of a properly functioning, newly implanted pacing system has not to our knowledge been described. We report such a case to stress the need for caution when using this drug in elderly pacemaker patients.
醋酸氟卡尼是一种最近引入的Ⅰ类抗心律失常药物，对治疗室性及房室/结折返性心动过速非常有效。虽然已知静脉注射和口服氟卡尼都会导致起搏阈值升高，但据我们所知，尚未有因阈值突然且可能致命性升高而导致功能正常的新植入起搏系统失效的情况被描述。我们报告这样一例病例，以强调在老年起搏器患者中使用该药物时需谨慎。
