Kang Tae Soo, Yoon Young Won, Park Sungha, Hong Bum-Kee, Kim Dongsoo, Kwon Hyuck Moon, Kim Hyun-Seung
Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Gangnam-gu, Seoul 135-720, Korea.
Yonsei Med J. 2006 Feb 28;47(1):152-4. doi: 10.3349/ymj.2006.47.1.152.
Antiarrhythmic agents may increase capture threshold, but this is rarely of clinical significance. Flecainide acetate, a class IC agent, is reported to have a significant effect on the myocardial capture threshold. In this presentation, we report the case of a 72-year-old male, with a previously implanted VVI pacemaker due to sick sinus syndrome, who was treated with flecainide acetate for paroxysmal atrial arrhythmia control. During the fifteenth day of treatment, an abrupt rise in the ventricular capture threshold with ventricular pacing failure was noted. The capture threshold decreased two days after discontinuation of flecainide acetate.
抗心律失常药物可能会提高夺获阈值，但这在临床上很少具有重要意义。据报道，Ic类药物醋酸氟卡尼对心肌夺获阈值有显著影响。在本报告中，我们报道了一例72岁男性患者，因病态窦房结综合征曾植入VVI起搏器，该患者接受醋酸氟卡尼治疗以控制阵发性房性心律失常。在治疗的第15天，发现心室夺获阈值突然升高并出现心室起搏失败。停用醋酸氟卡尼两天后，夺获阈值降低。
