Michels-van Amelsfort J M R, Brand H S, van Laar J M
Uit de afdeling Reumatologie en Klinische Immunologie van bet Universitair Medisch Centrum Utrecht.
Ned Tijdschr Tandheelkd. 2013 Sep;120(9):446-50. doi: 10.5177/ntvt.2013.09.13179.
Systemic sclerosis is a relatively rare connective tissue disorder, in which a severe and progressive fibrosis of the skin and sometimes also of internal organs often develops as a result of an increased deposition of collagen. Fibrosis of the salivary glands may cause hyposalivation and xerostomia. Fibrosis of the perioral skin reduces the maximum opening of the mouth, thereby hampering dental treatment and the maintenance of oral hygiene. Periodontitis and bone resorption ofthe jaws are more frequently observed in systemic sclerosis patients.
系统性硬化症是一种相对罕见的结缔组织疾病，其中皮肤有时还有内脏器官会因胶原蛋白沉积增加而经常出现严重且进行性的纤维化。唾液腺纤维化可能导致唾液分泌减少和口干。口周皮肤纤维化会减小口腔最大开口度，从而妨碍牙科治疗和口腔卫生的维持。系统性硬化症患者中更常观察到牙周炎和颌骨骨质吸收。
