Selifanova E I, Makeeva M K, Turkina A Yu, Esayan M S
First Moscow State Medical University, Moscow, Russia.
Peoples friendship university of Russia, Moscow, Russia.
Stomatologiia (Mosk). 2019;98(3):104-108. doi: 10.17116/stomat201998031104.
The aim of this study was to conduct literature review about oral manifestations of scleroderma. Systemic sclerosis is a multisystem autoimmune disorder characterized by widespread fibrosis, vascular alterations and inflammation. Systemic sclerosis mainly affects people in age from 30 to 50 years, but the onset of disease can occur in any age. The disturbance of microcirculation with the activation and proliferation of endothelium and smooth muscle cells plays an important role in pathogenesis of sclerodrma. These changes lead to sclerosis and fibrosis of various part in human body. Orofacial manifestations of scleroderma include: reduced mouth opening, widening of periodontal ligament, teleangiectasia, bone lesions. Systemic scleroderma is often accompanied by Sjogren's syndrome. Oral manifestations of Sjogren's syndrome are recurrent parotitis, angular cheilitis, xerostomia and multiple caries. Sjogren's syndrome leads to negative impact on patients health and mental status. Orofacial manifestations of systemic sclerosis are still poorly known, that is why more researches should be made to improve dental treatment of patients with systemic sclerosis.
本研究的目的是对硬皮病的口腔表现进行文献综述。系统性硬化症是一种多系统自身免疫性疾病，其特征为广泛的纤维化、血管改变和炎症。系统性硬化症主要影响30至50岁的人群，但疾病可在任何年龄发病。微循环障碍以及内皮细胞和平滑肌细胞的激活与增殖在硬皮病的发病机制中起重要作用。这些变化导致人体各部位的硬化和纤维化。硬皮病的口面部表现包括：张口受限、牙周膜增宽、毛细血管扩张、骨病变。系统性硬化症常伴有干燥综合征。干燥综合征的口腔表现为复发性腮腺炎、口角炎、口干症和多发性龋齿。干燥综合征会对患者的健康和精神状态产生负面影响。系统性硬化症的口面部表现仍鲜为人知，这就是为什么需要进行更多研究以改善系统性硬化症患者的牙科治疗。
