1] Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Ya'an, China. [2] Biodynamic Optical Imaging Center (BIOPIC), Peking-Tsinghua Center for Life Sciences and School of Life Sciences, Peking University, Beijing, China. [3].
Nat Genet. 2013 Dec;45(12):1431-8. doi: 10.1038/ng.2811. Epub 2013 Oct 27.
We report the sequencing at 131× coverage, de novo assembly and analyses of the genome of a female Tibetan wild boar. We also resequenced the whole genomes of 30 Tibetan wild boars from six major distributed locations and 18 geographically related pigs in China. We characterized genetic diversity, population structure and patterns of evolution. We searched for genomic regions under selection, which includes genes that are involved in hypoxia, olfaction, energy metabolism and drug response. Comparing the genome of Tibetan wild boar with those of neighboring Chinese domestic pigs further showed the impact of thousands of years of artificial selection and different signatures of selection in wild boar and domestic pig. We also report genetic adaptations in Tibetan wild boar that are associated with high altitudes and characterize the genetic basis of increased salivation in domestic pig.
我们报道了一头雌性西藏野猪的测序数据，测序深度为 131×，从头组装并分析了其基因组。我们还对来自六个主要分布地点的 30 头西藏野猪和中国的 18 头地理相关的猪进行了全基因组重测序。我们描述了遗传多样性、群体结构和进化模式。我们还寻找了受选择影响的基因组区域，其中包括参与低氧、嗅觉、能量代谢和药物反应的基因。将西藏野猪的基因组与邻近的中国家猪的基因组进行比较，进一步显示了数千年的人工选择和野猪与家猪的选择特征的影响。我们还报告了与高海拔相关的西藏野猪的遗传适应性，并描述了家猪唾液分泌增加的遗传基础。
