Pirie R S
Royal (Dick) School of Veterinary Studies and Roslin Institute, University of Edinburgh, Roslin, Midlothian, UK.
Equine Vet J. 2014 May;46(3):276-88. doi: 10.1111/evj.12204. Epub 2014 Jan 7.
Recurrent airway obstruction is a widely recognised airway disorder, characterised by hypersensitivity-mediated neutrophilic airway inflammation and lower airway obstruction in a subpopulation of horses when exposed to suboptimal environments high in airborne organic dust. Over the past decade, numerous studies have further advanced our understanding of different aspects of the disease. These include clarification of the important inhaled airborne agents responsible for disease induction, improving our understanding of the underlying genetic basis of disease susceptibility and unveiling the fundamental immunological mechanisms leading to establishment of the classic disease phenotype. This review, as well as giving a clinical overview of recurrent airway obstruction, summarises much of the work in these areas that have culminated in a more thorough understanding of this debilitating disease.
复发性气道阻塞是一种广为人知的气道疾病，其特征是在一群马匹暴露于空气中有机粉尘含量高的非最佳环境时，由超敏反应介导的嗜中性气道炎症和下气道阻塞。在过去十年中，大量研究进一步深化了我们对该疾病不同方面的认识。这些研究包括明确导致疾病诱发的重要吸入性空气传播因子，增进我们对疾病易感性潜在遗传基础的理解，以及揭示导致经典疾病表型形成的基本免疫机制。本综述除了对复发性气道阻塞进行临床概述外，还总结了这些领域的许多工作，这些工作最终使我们对这种使人衰弱的疾病有了更全面的理解。
