Periodontology Section, Department of Oral Sciences, Faculty of Medicine, Catholic University Leuven, Leuven, Belgium; Periodontology Section, Dentistry, University Hospitals Leuven, Leuven, Belgium; Fund for Scientific Research Flanders (FWO), Brussels, Belgium.
J Clin Periodontol. 2013 Nov;40(11):1025-35. doi: 10.1111/jcpe.12155. Epub 2013 Sep 15.
The aim of this randomized placebo-controlled clinical trial was to evaluate the effects of Lactobacillus reuteri-containing probiotic lozenges as an adjunct to scaling and root planing (SRP).
Thirty chronic periodontitis patients were recruited and monitored clinically and microbiologically at baseline, 3, 6, 9 and 12 weeks after therapy. All patients received one-stage full-mouth disinfection and randomly assigned over a test (SRP + probiotic, n = 15) or control (SRP + placebo, n = 15) group. The lozenges were used two times a day for 12 weeks.
At week 12, all clinical parameters were significantly reduced in both groups, while there was significantly more pocket depth reduction (p < 0.05) and attachment gain (p < 0.05) in moderate and deep pockets; more Porphyromonas gingivalis reduction was observed in the SRP + probiotic group.
The results indicate that oral administration of L. reuteri lozenges could be a useful adjunct to SRP in chronic periodontitis.
本随机安慰剂对照临床试验的目的是评估含有罗伊氏乳杆菌的益生菌含片作为辅助治疗刮治和根面平整（SRP）的效果。
招募了 30 名慢性牙周炎患者，在治疗前、治疗后 3、6、9 和 12 周进行临床和微生物学监测。所有患者均接受了一次性全口消毒，并随机分配到实验组（SRP+益生菌，n=15）或对照组（SRP+安慰剂，n=15）。含片每天使用两次，持续 12 周。
第 12 周时，两组的所有临床参数均显著降低，而中深牙周袋的探诊深度减少（p<0.05）和附着丧失增加（p<0.05）更为显著；在 SRP+益生菌组中观察到牙龈卟啉单胞菌的减少更为显著。
结果表明，口服罗伊氏乳杆菌含片可能是慢性牙周炎辅助 SRP 的一种有效方法。
