Vanditha Dasari, B V Ramesh Reddy, Chava Vijay Kumar, Biradavolu Sukrutha, Nagarakanti Sreenivas, Gunupati Sumanth
Department of Periodontology, Narayana Dental College and Hospital, Nellore, IND.
Department of Periodontology, Mamatha Institute of Dental Sciences, Hyderabad, IND.
Cureus. 2025 Jan 14;17(1):e77413. doi: 10.7759/cureus.77413. eCollection 2025 Jan.
Periodontal disease is a chronic microbial infection characterized by inflammation and destruction of periodontal tissues. Probiotics, such as , offer potential benefits in periodontal therapy due to their antimicrobial and anti-inflammatory properties. This study aimed to evaluate the clinical and microbiological efficacy of locally administered biodegradable fibers containing as an adjunct to scaling and root planing (SRP) in managing chronic periodontitis.
A single-center, double-blind, placebo-controlled, parallel-arm, randomized clinical trial was conducted with 30 patients aged 30-60 years diagnosed with chronic periodontitis were randomized into test (SRP + probiotic fiber) and control (SRP + placebo fiber) groups. Clinical parameters, including plaque index (PI), bleeding index (BI), probing pocket depth (PPD), clinical attachment level (CAL), and microbial load ( via quantitative reverse transcription-polymerase chain reaction (qRT-PCR)) were assessed at baseline and three months post-treatment. Quantification of was conducted using real-time quantitative PCR. The Shapiro-Wilk test assessed normality, and the Mann-Whitney U and Wilcoxon tests were used for inter- and intra-group comparisons.
Both groups showed significant improvements in clinical parameters (p<0.05). The test group achieved a 45.66% reduction in PI, 57.83% reduction in BI, and significant improvements in PPD (43.06%) and CAL (43.06%). Microbial load decreased more in the test group (63.00%) than in the control group (26.08%).
Adjunctive use of in biodegradable fiber form improves clinical outcomes, highlighting its potential as a non-invasive adjunctive treatment for chronic periodontitis. Further studies are warranted to validate long-term efficacy.
牙周病是一种慢性微生物感染，其特征为牙周组织的炎症和破坏。益生菌，如[具体益生菌名称未给出]，因其抗菌和抗炎特性，在牙周治疗中具有潜在益处。本研究旨在评估局部应用含[具体益生菌名称未给出]的可生物降解纤维作为龈上洁治和根面平整（SRP）辅助治疗慢性牙周炎的临床和微生物学疗效。
进行了一项单中心、双盲、安慰剂对照、平行组、随机临床试验，将30例年龄在30 - 60岁、诊断为慢性牙周炎的患者随机分为试验组（SRP + 益生菌纤维）和对照组（SRP + 安慰剂纤维）。在基线和治疗后三个月评估临床参数，包括菌斑指数（PI）、出血指数（BI）、探诊深度（PPD）、临床附着水平（CAL）以及微生物负荷（通过定量逆转录 - 聚合酶链反应（qRT - PCR））。使用实时定量PCR对[具体益生菌名称未给出]进行定量。采用Shapiro - Wilk检验评估正态性，Mann - Whitney U检验和Wilcoxon检验用于组间和组内比较。
两组的临床参数均有显著改善（p < 0.05）。试验组PI降低了45.66%，BI降低了57.83%，PPD（43.06%）和CAL（43.06%）也有显著改善。试验组的微生物负荷下降幅度（63.00%）大于对照组（26.08%）。
以可生物降解纤维形式辅助使用[具体益生菌名称未给出]可改善临床疗效，凸显了其作为慢性牙周炎非侵入性辅助治疗的潜力。有必要进一步开展研究以验证其长期疗效。
